Stereotactic body radiotherapy: a new paradigm in the management of spinal metastases

Author:

Husain Zain A1,Thibault Isabelle2,Letourneau Daniel3,Ma Lijun4,Keller Harald3,Suh John5,Chiang Veronica16,Chang Eric L7,Rampersaud Raja K8,Perry James9,Larson David A4,Sahgal Arjun310

Affiliation:

1. Department of Radiation Oncology, Yale School of Medicine, New Haven, CT, USA

2. Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, 610 University Avenue, Toronto, ON, M6G 2M5, Canada

3. Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada

4. Department of Radiation Oncology, University of California San Francisco, San Francisco, CA, USA

5. Department of Radiation Oncology, Cleveland Clinic, Cleveland, OH, USA

6. Department of Neurosurgery, Yale School of Medicine, New Haven, CT, USA

7. Department of Radiation Oncology, University of Southern California, Los Angeles, CA, USA

8. Department of Orthopedics, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada

9. Division of Neurology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada

10. Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, 610 University Avenue, Toronto, ON, M6G 2M5, Canada. .

Abstract

SUMMARY Spine stereotactic body radiotherapy is based on delivering high biologically effective doses to spinal metastases, with the intent to maximize both tumor and pain control. The purpose of this review is to outline the technical details of spine stereotactic body radiotherapy, contrast clinical outcomes to low biologically effective dose conventional palliative radiotherapy, discuss the role of surgery in the era of spine stereotactic body radiotherapy, and summarize the major serious adverse events that patients would otherwise not be at risk of with conventional radiotherapy.

Publisher

Future Medicine Ltd

Subject

General Medicine

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