<i>In vitro</i> activity of the novel Fe-cyclam complex against clinical multidrug-resistant bacterial isolates from Brazil-Reference-Cited by-同舟云学术

In vitro activity of the novel Fe-cyclam complex against clinical multidrug-resistant bacterial isolates from Brazil

Published:2023-09 Issue:13 Volume:18 Page:897-909
ISSN:1746-0913
Container-title:Future Microbiology
language:en
Short-container-title:Future Microbiology

Author:

Polo Ana B¹^ORCID,Lemos Ari SO¹^ORCID,Martins da Mata Camila PS²^ORCID,Oliveira Verônica S³^ORCID,Pontes Ana CFB³^ORCID,Pontes Daniel L³^ORCID,Tavares Guilherme D⁴^ORCID,Fabri Rodrigo L¹^ORCID,M Apolônio Ana Carolina¹^ORCID

Affiliation:

1. Institute of Biological Sciences, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, 36036-900, Brazil

2. Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, 31270-901, Brazil

3. Institute of Chemistry, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, 59078-970, Brazil

4. Laboratory of Nanostructured Systems Development, Department of Pharmaceutical Science, Faculty of Pharmacy, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, 36036-900, Brazil

Abstract

Aim: To evaluate the effect of a new Fe-cyclam complex on pathogenic bacterial species, including multidrug-resistant clinical specimens. Materials & methods: The complex [Fe(cyclam)ox]PF6 (D2) was tested in cytotoxicity and MIC tests. Clinical and reference strains of Gram-negative and Gram-positive bacteria were used. Considering Staphylococcus aureus strains, the profile of antimicrobial susceptibility and time–kill kinetics for D2 was performed. An in silico analysis for D2 was also performed. Results: D2 showed broad bacterial activity, mainly against specimens of Cutibacterium acnes, S. aureus, Pseudomonas aeruginosa and Acinetobacter baumannii. Low cytotoxicity in human cells was demonstrated. Conclusion: The tested compound proved to be a promising agent against resistant bacterial infections.

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fmb-2023-0058

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