Cyclodextrin inclusion complexes improving antibacterial drug profiles: an update systematic review

Author:

Santos Anamaria M1ORCID,Júnior José ACN2ORCID,Cézar Silvia VS3,Araújo Adriano AS123ORCID,Júnior Lucindo JQ12ORCID,Aragón Diana M4ORCID,Serafini Mairim R123ORCID

Affiliation:

1. Postgraduate Program in Health Sciences, Federal University of Sergipe, Aracaju, 49060-100, Sergipe, Brazil

2. Postgraduate Program in Pharmaceutical Sciences, Federal University of Sergipe,São Cristóvão, 49060-100, Sergipe, Brazil

3. Department of Pharmacy,Federal University of Sergipe, São Cristóvão, 49060-100, Sergipe, Brazil

4. Departamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia, Bogotá D.C., Colombia

Abstract

Aim: The study aimed to review experimental models using cyclodextrins to improve antibacterial drugs' physicochemical characteristics and biological activities. Methods: The following terms and their combinations were used: cyclodextrins and antibacterial agents in title or abstract, and the total study search was conducted over a period up to October 2022. The review was carried out using PubMed, Scopus and Embase databases. A total of 1580 studies were identified, of which 27 articles were selected for discussion in this review. Results: The biological results revealed that the antibacterial effect of the inclusion complexes was extensively improved. Cyclodextrins can enhance the therapeutic effects of antibiotics already existing on the market, natural products and synthetic molecules. Conclusion: Overall, CDs as drug-delivery vehicles have been shown to improve antibiotics solubility, stability, and bioavailability, leading to enhanced antibacterial activity.

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

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