Big Data in traumatic brain injury; promise and challenges

Author:

Agoston Denes V12,Langford Dianne3

Affiliation:

1. Department of Anatomy, Physiology & Genetics, Uniformed Services University, Bethesda, MD 20814, USA

2. Department of Neuroscience, Karolinska Institute, Stockholm, Sweden

3. Department of Neuroscience, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA

Abstract

Traumatic brain injury (TBI) is a spectrum disease of overwhelming complexity, the research of which generates enormous amounts of structured, semi-structured and unstructured data. This resulting big data has tremendous potential to be mined for valuable information regarding the “most complex disease of the most complex organ”. Big data analyses require specialized big data analytics applications, machine learning and artificial intelligence platforms to reveal associations, trends, correlations and patterns not otherwise realized by current analytical approaches. The intersection of potential data sources between experimental TBI and clinical TBI research presents inherent challenges for setting parameters for the generation of common data elements and to mine existing legacy data that would allow highly translatable big data analyses. In order to successfully utilize big data analyses in TBI, we must be willing to accept the messiness of data, collect and store all data and give up causation for correlation. In this context, coupling the big data approach to established clinical and pre-clinical data sources will transform current practices for triage, diagnosis, treatment and prognosis into highly integrated evidence-based patient care.

Publisher

Future Medicine Ltd

Subject

Neurology (clinical),Neurology

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