Analysis of the antifungal potential of <i>Macrocybe titans</i> extract against <i>Candida albicans</i>-Reference-Cited by-同舟云学术

Analysis of the antifungal potential of Macrocybe titans extract against Candida albicans

Published:2023-04 Issue:6 Volume:18 Page:357-371
ISSN:1746-0913
Container-title:Future Microbiology
language:en
Short-container-title:Future Microbiology

Author:

Pereira Fernanda CBN¹,Peiter Gabrielle C¹^ORCID,Justo Vivian EMS²,Huff Gabrieli M²^ORCID,Conrado Pollyanna CV³^ORCID,da Silva Mauro AP²,Bonfim-Mendonça Patrícia S³^ORCID,Svidzinski Terezinha IE³^ORCID,Rosado Fabio R²^ORCID,Fiorini Adriana²^ORCID

Affiliation:

1. Multicentric Graduate Program in Biochemistry & Molecular Biology, Federal University of Paraná, Palotina, Paraná, Brazil. Zip Code: 85950-000.

2. Department of Biosciences, Federal University of Paraná, Palotina, Paraná, Brazil. Zip Code: 85950-000.

3. Department of Clinical Analysis & Biomedicine, Laboratory of Medical Mycology, State University of Maringá, Maringá, Paraná, Brazil. Zip Code: 87020-900

Abstract

Aim: To investigate the antifungal potential of Macrocybe titans extracts against Candida albicans. Material & methods: Extracts were obtained as aqueous (EfraMat-22 and EfraMat-45) and methanolic/ethyl acetate fractions. Results: Broth microdilution and disk diffusion assays showed that EfraMat-45 provided the best results in terms of minimum inhibitory concentration. Scanning electron microscopy analysis revealed morphological changes and slight damage on the surfaces of cells exposed to EfraMat-45 at the MIC. Fluorescence microscopy analysis of the yeasts showed cell elongation. EfraMat-45 presented high levels of phenolic compounds and flavonoids, high antioxidant activity and absence of in vitro cytotoxicity. Conclusion: The results indicated that the aqueous extract of M. titans is highly promising as an antifungal agent.

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fmb-2022-0214

Reference38 articles.

1. Cell Cycle Dynamics and Quorum Sensing in Candida albicans Chlamydospores Are Distinct from Budding and Hyphal Growth

2. Implicações dos transgênicos na sustentabilidade ambiental e agrícola

3. Biologically Active Compounds from Aphyllophorales (Polypore) Fungi