Analysis of the antifungal potential of Macrocybe titans extract against Candida albicans

Author:

Pereira Fernanda CBN1,Peiter Gabrielle C1ORCID,Justo Vivian EMS2,Huff Gabrieli M2ORCID,Conrado Pollyanna CV3ORCID,da Silva Mauro AP2,Bonfim-Mendonça Patrícia S3ORCID,Svidzinski Terezinha IE3ORCID,Rosado Fabio R2ORCID,Fiorini Adriana2ORCID

Affiliation:

1. Multicentric Graduate Program in Biochemistry & Molecular Biology, Federal University of Paraná, Palotina, Paraná, Brazil. Zip Code: 85950-000.

2. Department of Biosciences, Federal University of Paraná, Palotina, Paraná, Brazil. Zip Code: 85950-000.

3. Department of Clinical Analysis & Biomedicine, Laboratory of Medical Mycology, State University of Maringá, Maringá, Paraná, Brazil. Zip Code: 87020-900

Abstract

Aim: To investigate the antifungal potential of Macrocybe titans extracts against Candida albicans. Material & methods: Extracts were obtained as aqueous (EfraMat-22 and EfraMat-45) and methanolic/ethyl acetate fractions. Results: Broth microdilution and disk diffusion assays showed that EfraMat-45 provided the best results in terms of minimum inhibitory concentration. Scanning electron microscopy analysis revealed morphological changes and slight damage on the surfaces of cells exposed to EfraMat-45 at the MIC. Fluorescence microscopy analysis of the yeasts showed cell elongation. EfraMat-45 presented high levels of phenolic compounds and flavonoids, high antioxidant activity and absence of in vitro cytotoxicity. Conclusion: The results indicated that the aqueous extract of M. titans is highly promising as an antifungal agent.

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

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