Essential oil of <i>Gallesia integrifolia</i> is active against mycobacteria-Reference-Cited by-同舟云学术

Essential oil of Gallesia integrifolia is active against mycobacteria

Published:2023-01 Issue:2 Volume:18 Page:107-116
ISSN:1746-0913
Container-title:Future Microbiology
language:en
Short-container-title:Future Microbiology

Author:

Montaholi Débora C¹^ORCID,Valverde Tamires L¹^ORCID,Sampiron Eloísa G¹^ORCID,Bortoluci Wanessa C²,Gazim Zilda C²,Caleffi-Ferracioli Katiany R³,Scodro Regiane BL¹,Siqueira Vera LD³,Cardoso Rosilene F¹

Affiliation:

1. Postgraduate Program in Health Sciences, State University of Maringa, Maringa, Parana, 87020-900, Brazil

2. Postgraduate Program in Biotechnology Applied to Agriculture, Paranaense University, Umuarama, Parana, 87502-210, Brazil

3. Postgraduate Program in Bioscience & Physiopathology, State University of Maringa, Maringa, Parana, 87020-900, Brazil

Abstract

Background: There is critical need for new therapeutic options for treatment of diseases caused by mycobacteria. Materials & methods: Gallesia integrifolia essential oils (EOs) and crude extracts (CEs) were tested for their anti- Mycobacterium tuberculosis and anti-nontuberculous mycobacteria activity. Results: Minimum inhibitory concentration (MIC) of EOs ranged from 15.63 to 62.5 μg/ml against M. tuberculosis and 62.5 to >250 μg/ml against nontuberculous mycobacteria. CEs showed low activity. All EO tested demonstrated synergism with antituberculosis drugs. The cytotoxicity of EOs and CEs, in different cell lines, showed selectivity index from 2.2 to 9.8 and >0.056 to 2.0, respectively. Conclusion: G. integrifolia EOs are a candidate for the development of new therapeutic options in the treatment of tuberculosis and other mycobacterial diseases.

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fmb-2022-0142

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