Multilocus sequence typing of <i>Treponema pallidum pallidum</i> in children with acquired syphilis by nonsexual contact-Reference-Cited by-同舟云学术

Multilocus sequence typing of Treponema pallidum pallidum in children with acquired syphilis by nonsexual contact

Published:2022-11 Issue:16 Volume:17 Page:1295-1305
ISSN:1746-0913
Container-title:Future Microbiology
language:en
Short-container-title:Future Microbiology

Author:

Garcia Luciana N¹²^ORCID,Morando Nicolás³,Otero Adrián V¹,Moroni Samanta¹^ORCID,Moscatelli Guillermo F¹²^ORCID,Gonzalez Nicolás¹^ORCID,D Slojan Alejandra¹,Lascano Fernanda¹²^ORCID,Ballering Griselda¹,Pando Maria A³,Altcheh Jaime M¹²^ORCID

Affiliation:

1. Servicio Parasitología-Chagas, Hospital de Niños Ricardo Gutierrez, Capital Federal, Buenos Aires, Argentina

2. Instituto Multidisciplinario de Investigaciones en Patologías Pediátricas (IMIPP), CONICET – GCBA, Buenos Aires, Argentina

3. Instituto de Investigaciones Biomédicas en Retrovirus y Sida (INBIRS) CONICET-Universidad de Buenos Aires, Buenos Aires, Argentina

Abstract

Background: There are scarce data of Treponema pallidum subsp. pallidum (TPA) characterization in children with syphilis. Nonsexually acquired transmission (NSAT) of TPA is possible in infants through close contact. Methods: A descriptive study in five families with NSAT of syphilis was conducted. Polymerase chain reaction detection of TPA in pediatric index cases (n = 6) and their relatives (n = 44) were conducted followed by multilocus sequence typing (MLST). Results: TPA was detected in swab samples in 16 cases and 12 were characterized by MLST. Nichols lineage was identified in two of five families and SS14-lineage in three of five. In four families, MLST profiles linked index cases to relatives. Conclusion: This is the first report of TPA characterization in children infected by NSAT.

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fmb-2022-0064

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