Long-term outcomes of pediatric infections: from traditional infectious diseases to long Covid

Author:

Buonsenso Danilo12ORCID,Gennaro Leonardo Di3,Rose Cristina De1,Morello Rosa1,D'Ilario Federico1,Zampino Giuseppe1,Piazza Michele4,Boner Attilio L4,Iraci Cecilia5,O'Connell Sarah6,Cohen Valentina B7,Esposito Susanna8,Munblit Daniel9,Reena Joseph10,Sigfrid Louise11,Valentini Piero1

Affiliation:

1. Department of Woman & Child Health & Public Health, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy

2. Center for Global Health Research & Studies, Università Cattolica del Sacro Cuore, Roma, Italia

3. Department of Diagnostic Imaging, Hemorrhagic & Thrombotic Diseases Center, Oncological Radiotherapy, & Hematology, Foundation ‘A Gemelli’ IRCCS University Hospital, Rome, Italy

4. Pediatric Section, Department of Surgery, Dentistry, pediatrics, & Gynaecology, University of Verona, Verona, Italy

5. Patient author, Italy

6. Patient author, UK & Northern Ireland

7. Patient author, member of the CAC Community Advisory Council of Solve ME/CFS Initiative, Pietro Barilla Children's Hospital, Department of Medicine & Surgery, University of Parma, Via Gramsci 14, Parma, 43126, Italy

8. Pietro Barilla Children's Hospital, Department of Medicine & Surgery, University of Parma, Via Gramsci 14, Parma, 43126, Italy

9. Department of pediatrics & pediatric Infectious Diseases, Institute of Child's Health, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation

10. MSc Immunology, Imperial College London, London, UK

11. ISARIC Global Support Centre, Centre for Tropical Medicine & Global Health, University of Oxford, Oxford, UK

Abstract

There is limited evidence available on the long-term impact of SARS-CoV-2 infection in children. In this article, the authors analyze the recent evidence on pediatric long Covid and lessons learnt from a pediatric post-Covid unit in Rome, Italy. To gain a better understanding of the concerns raised by parents and physicians in relation to the potential long-term consequences of this novel infection, it is important to recognize that long-term effect of a post-infectious disease is not a new phenomenon.

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

Reference140 articles.

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3. Word Health Organization. A clinical case definition of post COVID-19 condition by a Delphi consensus, 6 October 2021. www.who.int/publications/i/item/WHO-2019-nCoV-Post_COVID-19_condition-Clinical_case_definition-2021.1

4. Life-threatening bronchiolitis in children: eight decades of critical care

5. Risk factors for recurrent wheezing after bronchiolitis in infants: 2-year follow up in China

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