Otomycosis caused by the cryptic and emerging species Aspergillus sydowii: two case reports

Author:

Buonafina-Paz Maria DS1ORCID,Santos Franz AG1ORCID,Leite-Andrade Melyna C1ORCID,Alves Adryelle IS1ORCID,Bezerra Jadson DP2ORCID,Leal Mariana C1ORCID,Robert Estelle3,Pape Patrice Le3ORCID,Lima-Neto Reginaldo G1ORCID,Neves Rejane P1ORCID

Affiliation:

1. Federal University of Pernambuco, Recife, Pernambuco, 50670901, Brazil

2. Federal University of Goiás, Goiânia, Goiás, 74690900, Brazil

3. Faculté des Sciences Pharmaceutiques et Biologiques, Université de Nantes, Nantes, 44035, France

Abstract

Two cases of otomycosis have been reported in patients undergoing tympanomastoidectomy. The first one had chronic otitis media, hypertrophic concha and nasal septum deviation, tympanic perforation and otorrhea. The second had otalgia, pruritus, chronic otitis media and cholesteatoma. Direct examination showed mycelial septate filaments with a branch at an angle close to 45°, later identified as Aspergillus sydowii by sequencing the BenA and CaM genes. Susceptibility testing showed low MIC of amphotericin B, itraconazole, ketoconazole and ciclopirox olamine. In both cases, ketoconazole was instituted for 10 days. Otomycosis is a challenge as it is primarily recurrent in patients undergoing surgery. The clinical implication, the identification of the emerging pathogen and the determination of MIC were necessary for the knowledge of the epidemiological profile and establishment of the treatment.

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3