Gonococci resistant to current antimicrobial management standards: a new threat to global public health

Author:

dos Santos Tauanne F1ORCID,Goveia Mellânia R1ORCID,Moraes Gleyson MA1ORCID,Tavares Marco ASB2ORCID,Davalos Silvio RA2ORCID,Campos Camila BS1ORCID,de Oliveira Fernando A3ORCID,Benitez Diego FD3ORCID,Tavares Maria B1ORCID,Colli Emillene de H1ORCID,Pinheiro Maria EL1ORCID,Rodrigues Barbara dos RDL1ORCID,Neto Celso DLR1ORCID,Ribeiro Rafaela S1ORCID

Affiliation:

1. Anhanguera University, UNIDERP, Campo Grande, Brazil

2. Federal University of Mato Grosso do Sul, UFMS, Campo Grande, Brazil

3. Federal University of Mato Grosso, UFMT, Cuiabá, Brazil

Abstract

Gonorrhea is the second most common sexually transmitted bacterial infection on the planet and is caused by a Gram-negative cocco, Neisseria gonorrhoeae. Currently, the preferred regimen for the management of this disease in Brazil is a combination of antimicrobials, in this case, ceftriaxone and azithromycin. However, over time, the gonococcus developed a decrease in susceptibility to the regimen used, which resulted in frank resistance to antimicrobials, progressively reducing the therapeutic options available. Thus, the study presented here aims to analyze and discuss the current scenario of resistance of N. gonorrhoeae to the antimicrobials used to date, to encourage discussion on the subject in the academic environment. For this purpose, 47 articles indexed in the Bireme, PubMed, Scielo and UpToDate platforms were selected.

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

Reference47 articles.

1. CDC. Guidelines for the Treatment of Sexually Transmitted Diseases. GA, USA (2021). www.cdc.gov/std/gonorrhea/arg/carb.htm

2. WHO, Department of Reproductive Health and Research. WHO Guidelines for the Treatment of Neisseria gonorrhoeae. Geneva, Switzerland (2016). www.who.int/reproductivehealth/publications/rtis/gonorrhoeatreatment-guidelines/en/

3. Ministry of Health of Brazil, Department of Health Surveillance. Department of STD, AIDS and Viral Hepatitis. Clinical Protocol and Therapeutic Guidelines for Comprehensive Care for People with Sexually Transmitted Infections. Brasília, Brasil (2015). http://bvsms.saude.gov.br/bvs/publicacoes/protocolo_clinico_diretrizes_terapeutica_atencao_integral_pessoas_infeccoes_sexualmente_transmissiveis.pdf

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