Sertraline has fungicidal activity against <i>Candida</i> spp. and acts by inhibiting membrane and cell wall biosynthesis-Reference-Cited by-同舟云学术

Sertraline has fungicidal activity against Candida spp. and acts by inhibiting membrane and cell wall biosynthesis

Published:2023-11 Issue:15 Volume:18 Page:1025-1039
ISSN:1746-0913
Container-title:Future Microbiology
language:en
Short-container-title:Future Microbiology

Author:

Rodrigues Daniel S¹²^ORCID,Cabral Vitória PF¹²^ORCID,Barbosa Amanda D¹²^ORCID,Valente Sá Lívia GA¹²³^ORCID,Silva Cecília R¹²^ORCID,Moreira Lara EA¹²^ORCID,Neto Joao BA¹²³^ORCID,Silva Jacilene⁴,Santos Hélcio S⁵^ORCID,Marinho Emmanuel S⁴^ORCID,Cavalcanti Bruno C²^ORCID,Moraes Manoel O²,Nobre Júnior Hélio V¹²^ORCID

Affiliation:

1. School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, 430-372, Brazil

2. Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, 430-275, Brazil

3. Christus University Center (UNICHRISTUS), Fortaleza, CE, Brazil

4. Department of Chemistry, Group of Theoretical Chemistry and Electrochemistry (GQTE), State University of Ceará, Limoeiro do Norte, Ceará, 930-000, Brazil

5. Science and Technology Center, Chemistry Course, Vale do Acaraú State University, CE, 040-370, Sobral

Abstract

Aim: Our study evaluated the activity of sertraline (SER) alone and associated with antifungal drugs in planktonic Candida spp. strains, and investigated its mechanism of action. Materials & methods: Broth microdilution method and minimum fungicidal concentration/MIC ratio were used to assess SER anticandidal activity, and the interaction with antifungals was determined by fractional inhibitory concentration index. The mechanism of action was investigated by flow cytometry and in silico tests. Results: SER inhibited Candida spp. strains at low concentrations by the fungicidal effect and showed no loss of effectiveness when combined. Its action seemed to be related to the membrane and cell wall biosynthesis inhibition. Conclusion: SER has activity against Candida spp. isolated and associated with antifungals, and acts by causing cell wall and membrane damage.

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fmb-2022-0254

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