Lasmiditan for the acute treatment of migraine

Author:

DeJulio Paul A12ORCID,Perese Joshua K3ORCID,Schuster Nathaniel M4ORCID,Oswald Jessica C45ORCID

Affiliation:

1. Department of Emergency Medicine, The Ohio State University, OH 43210, USA

2. Department of Internal Medicine, The Ohio State University, OH 43210, USA

3. Department of Emergency Medicine, Loma Linda University Medical Center, CA 92354, USA

4. Department of Anesthesiology, Center for Pain Medicine, UC San Diego Health, CA 92103, USA

5. Department of Emergency Medicine, UC San Diego Health, CA 92103, USA

Abstract

Migraine is a leading cause of morbidity and disability worldwide. Triptans were the first migraine-specific drug class developed and have proven efficacy in treatment of this neurological disease. They are however contraindicated in patients with cardiovascular disease and possibly others, owning to their vasoconstrictive properties. This review will focus on lasmiditan, which has been called the first ‘ditan’ and ‘neurally acting anti-migraine agent’, designed to selectively agonize the serotonin 5-HT1F receptor subtype, providing anti-migraine effects without concomitant vasoconstriction. To date, lasmiditan has proven safe and effective for the acute treatment of migraine in two Phase II and four Phase III trials. Post hoc analysis revealed that the majority of treatment-emergent adverse events were CNS-related, mild-to-moderate in severity and self-limiting. The US FDA label recommends that patients not drive or operate machinery until at least 8 h after taking each dose of lasmiditan.

Publisher

Future Medicine Ltd

Subject

General Medicine

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