Human adipose-derived mesenchymal progenitor cells plus microfracture and hyaluronic acid for cartilage repair: a Phase IIa trial-Reference-Cited by-同舟云学术

Human adipose-derived mesenchymal progenitor cells plus microfracture and hyaluronic acid for cartilage repair: a Phase IIa trial

Published:2020-01 Issue:1 Volume:15 Page:1193-1214
ISSN:1746-0751
Container-title:Regenerative Medicine
language:en
Short-container-title:Regenerative Medicine

Author:

Qiao Zhiguang¹²,Tang Jiaxin¹³,Yue Bing⁴,Wang Jinwu¹,Zhang Jun¹,Xuan Liang¹,Dai Chengxiang⁵,Li Suke⁵,Li Meng⁵,Xu Cuili⁵,Dai Kerong⁴,Wang You¹²

Affiliation:

1. Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China

2. Medical 3D Printing Innovation Research Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200125, China

3. Department of Bone & Joint Surgery, Shanghai Fourth People’s Hospital Affiliated to Tongji University School of Medicine, Shanghai 200081, China

4. Department of Bone & Joint Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200020, China

5. Cellular Biomedicine Group, Shanghai 201210, China

Abstract

Aim: This study aimed to preliminarily evaluate the safety and efficacy of human adipose-derived mesenchymal progenitor cells (haMPCs) in combination with microfracture and hyaluronic acid (HA) for treating cartilage defects. Materials & methods: A total of 30 patients with medial femoro-tibial condylar cartilage defects were randomized into three groups: arthroscopic microfracture group and normal saline injection, arthroscopic microfracture and intra-articular injection of HA, or arthroscopic microfracture in combination with intra-articular injection of HA and haMPCs. Results & conclusions: The data demonstrated that intra-articular injection of haMPCs plus microfracture and HA is a safe procedure to improve joint function in patients with knee cartilage defects. These findings provide an impetus for future research on this treatment. ClinicalTrials.gov Identifier: NCT02855073

Publisher

Future Medicine Ltd

Subject

Embryology,Biomedical Engineering

Link

https://www.futuremedicine.com/doi/pdf/10.2217/rme-2019-0068

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