Human umbilical cord-mesenchymal stem cells: a promising strategy for corneal epithelial regeneration-Reference-Cited by-同舟云学术

Human umbilical cord-mesenchymal stem cells: a promising strategy for corneal epithelial regeneration

Published:2020-03 Issue:3 Volume:15 Page:1381-1397
ISSN:1746-0751
Container-title:Regenerative Medicine
language:en
Short-container-title:Regenerative Medicine

Author:

Azmi Siti Maisura¹,Salih Mohamed¹²,Abdelrazeg Samar¹²,Roslan Fatin Fazrina¹,Mohamed Rafeezul¹,Tan Jun Jie¹,Shaharuddin Bakiah¹^ORCID

Affiliation:

1. Regenerative Medicine Cluster, Advanced Medical and Dental Institute, Universiti Sains Malaysia, SAINS@BERTAM, Kepala Batas, Penang 13200, Malaysia

2. Faculty of Medical Laboratory Sciences, National University Sudan, Khartoum, Sudan

Abstract

Aim: As a strategy to improve the outcome of ex vivo cultivated corneal epithelial transplantation, the role of human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) is investigated in promoting corneal epithelial growth and functions. Materials & methods: Human telomerase-immortalized corneal epithelial cells were characterized and its functions evaluated by scratch migration assay, cellular senescence, HLA expression and spheres formation with hUC-MSC. Results: Expression of corneal epithelial markers was influenced by the duration and method of co-culture. Indirect co-culture improved cellular migration and delayed senescence when treated after 3 and 5 days. hUC-MSC downregulated expression of HLA Class I and II in IFN-γ-stimulated human telomerase-immortalized corneal epithelial cells. Conclusion: hUC-MSC promote corneal epithelial growth and functions after treatment with hUC-MSC.

Publisher

Future Medicine Ltd

Subject

Embryology,Biomedical Engineering

Link

https://www.futuremedicine.com/doi/pdf/10.2217/rme-2019-0103

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