Pharmacological PTEN inhibition: potential clinical applications and effects in tissue regeneration

Author:

Borges Gabriel A12,Webber Liana P1,M Marques Ana Elizia12,Guerra Eliete NS12,Castilho Rogerio M13,Squarize Cristiane H13

Affiliation:

1. Laboratory of Epithelial Biology, Department of Periodontics & Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI 48109-1078, USA

2. Laboratory of Oral Histopathology, Health Sciences Faculty, University of Brasília, Brasília, Brazil

3. The Michigan Medicine Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA

Abstract

Although the human body can heal, it takes time, and slow healing and chronic wounds often occur. Thus, identifying novel therapies to aid regeneration is needed. Here, we conducted a systematic review following the Preferred Reporting Items for Systematic Reviews guidelines and assessed preclinical studies on phosphatase and tensin homolog (PTEN) inhibitors and their effects on tissue repair and regeneration. In conditions associated with neurodegeneration, tissue injury and ischemia, the PTEN-regulated PI3K/AKT signaling pathway is activated. The use of PTEN inhibitors resulted in better tissue response by reducing the healing time and lesion sizes or inducing neuronal regeneration. Notably, all studies included in this systematic review indicated that pharmacological inhibition of PTEN enhanced the repair process of the eye, lung, muscle and nervous system.

Publisher

Future Medicine Ltd

Subject

Embryology,Biomedical Engineering

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