Bone regeneration in rabbit calvarial defects using PRGF and adipose-derived stem cells: histomorphometrical analysis-Reference-Cited by-同舟云学术

Bone regeneration in rabbit calvarial defects using PRGF and adipose-derived stem cells: histomorphometrical analysis

Published:2020-04 Issue:4 Volume:15 Page:1535-1549
ISSN:1746-0751
Container-title:Regenerative Medicine
language:en
Short-container-title:Regenerative Medicine

Author:

Stumbras Arturas¹,Kuliesius Povilas¹,Darinskas Adas²,Kubilius Ricardas¹,Zigmantaite Vilma³,Juodzbalys Gintaras¹

Affiliation:

1. Department of Maxillofacial Surgery, Faculty of Odontology, Lithuanian University of Health Sciences, Kaunas, Lithuania

2. Laboratory of Immunology, National Cancer Institute, Lithuania

3. Animal Research Centre, Lithuanian University of Health Sciences, Kaunas, Lithuania

Abstract

Aim: The aim of this study was to evaluate the osteogenic potential of adipose-derived stem cells (ADSCs) and to assess the influence of plasma rich in growth factors (PRGF) on bone regeneration using ADSCs. Materials & methods: Bone defects were randomly allocated to the five treatment modalities: spontaneous healing, natural bovine bone mineral (BBM), BBM loaded with PRGF, BBM loaded with ADSCs and BBM loaded with a combination of ADSCs and PRGF. Results: The PRGF significantly enhanced the biomaterial-to-bone contact. Defects treated with ADSCs and PRGF or a combination of both showed the greatest bone regeneration. Conclusion: Combining PRGF and ADSCs boosts the bone graft regenerative potential at the earliest period of healing.

Publisher

Future Medicine Ltd

Subject

Embryology,Biomedical Engineering

Link

https://www.futuremedicine.com/doi/pdf/10.2217/rme-2019-0123

Reference83 articles.

1. Ramus or Chin Grafts for Maxillary Sinus Inlay and Local Onlay Augmentation: Comparison of Donor Site Morbidity and Complications

2. Onlay augmentation versus sinuslift procedure in the treatment of the severely resorbed maxilla: a 5-year comparative longitudinal study

3. The Use of Combined Periodontal Regenerative Techniques

4. Leukocyte- and Platelet-Rich Fibrin (L-PRF) for Long-Term Delivery of Growth Factor in Rotator Cuff Repair: Review, Preliminary Results and Future Directions

5. Bone-Graft Substitutes: Facts, Fictions, and Applications

Cited by 4 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Incorporation of calcium phosphate cement into decellularized extracellular matrix enhances its bone regenerative properties;Colloids and Surfaces B: Biointerfaces;2024-12

2. Adjunctive Plasma Rich in Growth Factors in the Treatment of Osteomyelitis and Large Odontogenic Cysts Prior to Successful Implant Rehabilitation: Case Report;Dentistry Journal;2023-07-31

3. A Narrative Review of Cell-Based Approaches for Cranial Bone Regeneration;Pharmaceutics;2022-01-05

4. Osteogenic differentiation system based on biopolymer nanoparticles for stem cells in simulated microgravity;Biomedical Materials;2021-03-09