The promotion of salinomycin delivery to hepatocellular carcinoma cells through EGFR and CD133 aptamers conjugation by PLGA nanoparticles

Author:

Jiang Jianxin1,Chen Huaiwen12,Yu Chao1,Zhang Yingying3,Chen Meiyuan1,Tian She1,Sun Chengyi1

Affiliation:

1. Department of Biliary-Hepatic Surgery, Affiliated Hospital of Guiyang Medical College, 28 Guiyi Road, Guizhou 550001, Guiyang, Guizhou, China

2. International Join Cancer Institute, The Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, China

3. College of Pharmacy, The Second Military Medical University, 325 Guo He Road, Shanghai 200433, China

Abstract

Aims: To develop salinomycin-loaded poly(lactic-co-glycolic acid) nanoparticles conjugated with both CD133 aptamers A15 and EGFR aptamers CL4 (CESN), to target hepatocellular carcinoma (HCC) cells simultaneously expressing EGFR and CD133. Materials & methods: The antitumor activity and mechanism of CESN were investigated. Results & conclusion: The cytotoxicity of CESN in HCC cells and CD133+ HCC cells was superior to that of A15 or CL4-conjugted or nontargeted salinomycin-loaded nanoparticles. The antitumor assay in mice bearing HCC xenograft tumors confirmed the superior antitumor activity of CESN over other controls. We speculated that the improved therapeutic effect of CESN may be attributed to both targeting a higher percentage of HCC cells and increased delivery of salinomycin to HCC cells.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

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