Evaluation of human papillomavirus type 197 genome in non-melanoma skin cancer and adjacent non-tumoral skin margins-Reference-Cited by-同舟云学术

Evaluation of human papillomavirus type 197 genome in non-melanoma skin cancer and adjacent non-tumoral skin margins

Published:2023-08 Issue:11 Volume:18 Page:699-704
ISSN:1746-0794
Container-title:Future Virology
language:en
Short-container-title:Future Virology

Author:

Vosough Zeinab¹^ORCID,Sadeghi Farzin²^ORCID,Kamrani Ghodsieh¹^ORCID,Hasanzadeh Ali³^ORCID,Ranaee Mohammad¹^ORCID

Affiliation:

1. Department of Pathology, School of Medicine, Babol University of Medical Sciences, Babol, 4717647745, Iran

2. Cellular & Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, 4717647745, Iran

3. Department of Microbiology, faculty of Medicine, Golestan University of Medical Sciences, Gorgan, 4934174515, Iran

Abstract

Aim: We aimed to investigate the presence of human papillomavirus type 197 (HPV197) in patients with cutaneous squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). Materials & methods: 58 formalin-fixed paraffin-embedded tissue samples, including 12 SCC and 46 BCC and the adjacent non-tumoral skin of the same patient were analyzed for the presence of HPV197E6 gene, using a quantitative real-time PCR assay. Results: The HPV197E6 gene was identified in 12 tumor samples (7 BCC and 5 SCC), but not in the control group. Conclusion: Based on these results, a high copy number of HPV197E6 gene provides additional support for the role of HPV197 in skin cancer.

Funder

Babol University of Medical Sciences

Publisher

Future Medicine Ltd

Subject

Virology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fvl-2023-0022

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