Evaluation of CLOCK and CSNK1D function in circadian rhythm signaling pathways in HTLV-1 carriers

Author:

Ekhtiari Mohadeseh1,Bastan Fatemeh1,Rashidian Maryam1,Safavi Mahshid1,Yaslianifard Somayeh2,Ashrafi Jafar2,Kermanian Fatemeh3,Mozhgani Sayed-Hamidreza24ORCID

Affiliation:

1. Student Research Committee, Alborz University of Medical Sciences, Karaj, Iran

2. Department of Microbiology and Virology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran

3. Department of Anatomy, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran

4. Non-communicable Disease Research Center, Alborz University of Medical Sciences, Karaj, Iran

Abstract

Aim: Disruption of the internal circadian rhythm pathway could lead to a range of diseases. In this study, we aim to evaluate the circadian rhythm pathway by assessing the interaction between CLOCK and CSNK1D genes in HTLV-1 carriers in comparison with healthy individuals. Materials & methods: CLOCK and CSNK1D gene expression was assessed using the RT-qPCR. Pathogenesis-related signaling networks were designed and analyzed using the obtained results. Results: There was no significant difference in age between the groups. CLOCK and CSNK1D gene expression levels were significantly higher in carriers than in healthy individuals (p = 0.04, p = 0.03, respectively). Conclusion: In addition to introducing potential biological markers, obtained results could be a good idea to further investigate this signaling pathway in the future.

Funder

Alborz University of Medical Sciences

Publisher

Future Medicine Ltd

Subject

Virology

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