Plasma IL-10, IL-19 and IL-32 are potential biomarkers for adenovirus-induced severe pneumonia in pediatric patients

Abstract

Aim: This study aimed to identify potential plasma biomarkers for severe pediatric adenovirus (AdV) infection. Methods: Thirty-seven inflammatory proteins were measured in the plasma of AdV-infected, influenza H3N2-infected or healthy pediatric participants and the prediction values of selected inflammatory proteins for AdV and severe AdV were assessed. Results: The expression profiles of AdV- and H3N2-infected patients were largely similar, with only IL-2, IL-10, IL-19 and IL-32 showing pathogen-dependent expression. IL-10, IL-19 and IL-32, both individually and in combination, could predict AdV and severe AdV infection. Conclusion: Plasma IL-10, IL-19 and IL-32 are potential biomarkers for AdV, especially severe AdV in pediatric patients.