Analysis of amino acid changes in NS protein of influenza A/(H3N2) virus in Iranian isolates-Reference-Cited by-同舟云学术

Analysis of amino acid changes in NS protein of influenza A/(H3N2) virus in Iranian isolates

Published:2015-11 Issue:11 Volume:10 Page:1195-1206
ISSN:1746-0794
Container-title:Future Virology
language:en
Short-container-title:Future Virology

Author:

Dahiru Rogo Lawal¹²,Rezaei Farhad¹³,Shafiei-Jandaghi Nazanin Z¹³,Ghavami Nastaran¹³,Fatemi-Nasab Ghazal¹³,Mokhtari-Azad Talat¹³

Affiliation:

1. Department of Medical Virology, School of Public Health, Tehran University of Medical Sciences, International Campus, Tehran, Iran

2. Department of Medical Laboratory Science, Faculty of Allied Health Sciences, College of Health Sciences, Bayero University Kano, PMB 3011, Nigeria

3. National Influenza Center, Department of Medical Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Abstract

Aim: Roles of NS gene of influenza A virus in virulence and replication are well established but extent of its variation in seasonal influenza A (H3N2) viruses in Iran is not well known. Materials & methods: NS gene of 37 (A/H3N2) virus isolates were sequenced and analyzed for information on genetic changes. Results: Data analysis of NS1 protein revealed two amino acid substitutions E26K and Q193R in almost all strains. Substitutions in T58P in 27.0%, A86S in 13.5% and each of V11G, M81I and P85T in 2.7% Iranian strains were also observed. Mutations in NS2/NEP protein were observed in K36E, Q101L and F107S. Conclusion: Many mutations were observed for the first time in Iranian strains. Their function remains to be determined.

Publisher

Future Medicine Ltd

Subject

Virology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fvl.15.90

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