Effect of the rs1051730–rs16969968 variant and smoking cessation treatment: a meta-analysis-Reference-Cited by-同舟云学术

Effect of the rs1051730–rs16969968 variant and smoking cessation treatment: a meta-analysis

Published:2015-05 Issue:7 Volume:16 Page:713-720
ISSN:1462-2416
Container-title:Pharmacogenomics
language:en
Short-container-title:Pharmacogenomics

Author:

Leung Tiffany¹,Bergen Andrew²,Munafò Marcus Robert³,De Ruyck Kim¹,Selby Peter¹,De Luca Vincenzo¹

Affiliation:

1. CAMH, Department of Psychiatry, University of Toronto, 250 College St, M5T1R8, Toronto, Canada

2. SRI International, 333 Ravenswood, Menlo Park, CA 94025-3493, USA

3. University of Bristol, 12a Priory Road, Bristol, BS8 1TU, UK

Abstract

Objective: To assess if the allelic variations of rs16969968/rs1051730 in the CHRNA5–CHRNA3–CHRNB4 gene cluster are associated with smoking cessation after nicotine replacement therapy (NRT). Methods: We searched for NRT studies published from 2000–2013 that reported counts for allelic variation of rs16969968/rs1051730 and measured abstinence rates at the end of NRT treatment. We identified four studies which met the criteria, giving us a test sample of 2036 participants. Results: There was no effect of rs16969968/rs1051730 in influencing the success rate at the end of NRT (n = 6, effect size [ES]: 0.969, 95% CI: 0.77 to 1.23, z = 0.27, p = 0.791). Conclusion: There is no robust evidence that allelic variations of rs16969968 or rs1051730 are associated with smoking cessation after NRT. Original submitted 26 November 2014; Revision submitted 9 March 2015

Publisher

Future Medicine Ltd

Subject

Pharmacology,Genetics,Molecular Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/pgs.15.34

Reference43 articles.

1. How to prevent 100 million deaths from tobacco

2. A prospective cohort study challenging the effectiveness of population-based medical intervention for smoking cessation

3. Personalization and perceived personal relevance in computer-tailored persuasion in smoking cessation

4. Human neuronal acetylcholine receptor A5-A3-B4 haplotypes are associated with multiple nicotine dependence phenotypes

5. Variants in nicotinic acetylcholine receptors α5 and α3 increase risks to nicotine dependence

Cited by 21 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The effect of heavy smoking on retirement risk: A mendelian randomisation analysis;Addictive Behaviors;2024-10

2. Deep sequencing of candidate genes identified 14 variants associated with smoking abstinence in an ethnically diverse sample;Scientific Reports;2024-03-16

3. Association of Polymorphism CHRNA5 and CHRNA3 Gene in People Addicted to Nicotine;International Journal of Environmental Research and Public Health;2022-08-23

4. Nicotine Replacement Therapy;NeuroPsychopharmacotherapy;2022

5. Mendelian randomization in the multivariate general linear model framework;Genetic Epidemiology;2021-10-21