Genetic risk markers for hepatocellular carcinoma in patients with alcoholic liver disease

Author:

Nahon Pierre123,Sutton Angela45,Ziol Marianne267,Zucman-Rossi Jessica238910,Trinchet Jean-Claude1237,Ganne-Carrié Nathalie123

Affiliation:

1. Service d’Hépatologie, Hôpital Jean Verdier, AP-HP, Bondy, France

2. Université Paris 13, Sorbonne Paris Cité, UFR SMBH, F-93000 Bobigny, France

3. INSERM, UMR-1162, Génomique fonctionnelle des Tumeurs solides, équipe labellisée “Ligue Contre Le Cancer”, Paris, F-75010 France

4. Service de Biochimie, Hôpital Jean Verdier, AP-HP, Bondy, France

5. INSERM U1148, Sorbonne Paris Cité, UFR SMBH, F-93000 Bobigny, France

6. Service d’Anatomo-Pathologie, Hôpital Jean Verdier, AP-HP, Bondy, France

7. Centre de Ressources biologiques GH PSSD, Bondy, France

8. Université Paris Descartes, Labex Immuno-Oncology, Sorbonne Paris Cité, Faculté de Médecine, Paris, France

9. Université Paris Diderot, F-75013, Paris, France

10. Assistance Publique-Hôpitaux de Paris, Hopital Europeen Georges Pompidou, F-75015 Paris, France

Abstract

SUMMARY  Various single nucleotide polymorphisms have been reported to be associated with a higher risk of hepatocellular carcinoma in alcoholic cirrhotic patients. Until now, only common variants conferring a small increase in liver cancer risk have been identified. These inherited factors are able to modulate several biological pathways involved in alcohol-induced hepatocarcinogenesis, such as ethanol metabolism, inflammation, oxidative stress, or iron and lipid homeostasis. How the combination of these variants might collectively define an individual genomic risk prediction is currently being investigated. The other challenge in clinical practice lies in defining how to integrate this genetic information with other clinical parameters so as to refine selection of alcoholic cirrhotic patients according to various classes of hepatocellular carcinoma risk.

Publisher

Future Medicine Ltd

Subject

Oncology,Hepatology

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