Mesenchymal stem cells and thermal annular procedures for discogenic pain: a systematic review with pooled analysis-Reference-Cited by-同舟云学术

Mesenchymal stem cells and thermal annular procedures for discogenic pain: a systematic review with pooled analysis

Published:2024-01-26 Issue: Volume: Page:
ISSN:1758-1869
Container-title:Pain Management
language:en
Short-container-title:Pain Management

Author:

DesRochers John¹^ORCID,DesRochers Ryan¹,Patel Dev¹^ORCID,Andruszka Cassidy¹,Manchanda Shikhar¹,Ernazarov Akhmad¹,Mobley Aleesa²

Affiliation:

1. Rowan-Virtua School of Osteopathic Medicine, Stratford, NJ 08084, USA

2. Rowan Medicine NeuroMusculoskeletal Institute, Stratford, NJ 08084, USA

Abstract

Aim: Compare the effectiveness of mesenchymal stem cell injection therapies (MSC) and thermal annular procedures for the treatment of discogenic lower back pain. Materials & methods: A systematic review was performed following PRISMA 2020 guidelines. Pooled analysis was performed using patients' pain scores at baseline and at 12 months post-intervention. Results: Effect sizes based on change in pain score from baseline to 12 month follow-up revealed clinically significant improvement in pain score across all interventions. Conclusion: Minimally invasive interventions provide meaningful relief in discogenic back pain, with results suggesting promise for MSC injection therapies as a treatment model.

Publisher

Future Medicine Ltd

Subject

General Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/pmt-2023-0107

Reference31 articles.

1. Discogenic Low Back Pain

2. Prevalence and Characteristics of Discogenic Pain in Tertiary Practice: 223 Consecutive Cases Utilizing Lumbar Discography

3. Multipotent Mesenchymal Stem Cell Treatment for Discogenic Low Back Pain and Disc Degeneration

4. Effectiveness of Thermal Annular Procedures in Treating Discogenic Low Back Pain