Genetic polymorphisms associated with overweight and obesity in uncontrolled Type 2 diabetes mellitus-Reference-Cited by-同舟云学术

Genetic polymorphisms associated with overweight and obesity in uncontrolled Type 2 diabetes mellitus

Published:2016-04 Issue:4 Volume:10 Page:403-415
ISSN:1752-0363
Container-title:Biomarkers in Medicine
language:en
Short-container-title:Biomarkers in Medicine

Author:

Kasim Nor Bahirah¹,Huri Hasniza Zaman¹²,Vethakkan Shireene Ratna³,Ibrahim Luqman³,Abdullah Bashar Mudhaffar²

Affiliation:

1. Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia

2. Clinical Investigation Centre, Faculty of Medicine, 13th Floor Main Tower, University Malaya Medical Centre, 59100 Lembah Pantai Kuala Lumpur, Malaysia

3. Department of Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia

Abstract

Generally, obese and overweight individuals display higher free fatty acid levels, which stimulate insulin resistance. The combination of overweight or obesity with insulin resistance can trigger Type 2 diabetes mellitus (T2DM) and are primary contributing factors to the development of uncontrolled T2DM. Genetic polymorphisms also play an important role as they can impact a population's susceptibility to becoming overweight or obese and developing related chronic complications, such as uncontrolled T2DM. This review specifically examines the genetic polymorphisms associated with overweight and obesity in patients with uncontrolled T2DM. Particularly, gene polymorphisms in ADIPOQ (rs1501299 and rs17300539), LepR (rs1137101 and rs1045895), IRS2 (rs1805092), GRB14 (rs10195252 and rs3923113) and PPARG (rs1801282) have been associated with overweight and obesity in uncontrolled T2DM.

Publisher

Future Medicine Ltd

Subject

Biochemistry (medical),Clinical Biochemistry,Drug Discovery

Link

https://www.futuremedicine.com/doi/pdf/10.2217/bmm-2015-0037

Reference118 articles.

1. World Health Organization (WHO) (2012). www.who.int/mediacentre/events/annual/world_diabetes_day/en/index.htmls.

2. The Star Newspaper Online (2014). www.thestar.com.my/news/nation/2014/obesity-malaysia-highest-in-asia.

3. National Health and Morbidity Survey (NHMS). Diabetes Malaysia (2011).

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