Characterization of epigenetic and transcriptional landscape in infantile hemangiomas with ATAC-seq and RNA-seq-Reference-Cited by-同舟云学术

Characterization of epigenetic and transcriptional landscape in infantile hemangiomas with ATAC-seq and RNA-seq

Published:2020-06 Issue:11 Volume:12 Page:893-905
ISSN:1750-1911
Container-title:Epigenomics
language:en
Short-container-title:Epigenomics

Author:

Li Xueqing¹^ORCID,Chen Yuanzheng²,Fu Cong¹,Li Hongwen¹,Yang Kun¹,Bi Jianhai¹,Huo Ran¹

Affiliation:

1. Department of Plastic Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, PR China

2. Department of Burns & Plastic Surgery, Linyi People’s Hospital, Linyi, PR China

Abstract

Aim: This study was conducted to reveal epigenetic landscape in infantile hemangiomas (IHs) and identify transcription factors (TFs) and their downstream genes active in IHs. Materials & methods: We performed Assay for Transposase Accessible Chromatin (ATAC-seq) with RNA-seq in three pairs of IHs and their adjacent normal tissues. Functions of candidate TFs were investigated in human umbilical vein endothelial cells (HUVECs). Results: Chromatin of IH tissues is less compact. Some candidate genes and TFs were identified. In HUVECs, SPDEF inhibited cell viability and tube formation, and promoted apoptosis; SOX4 exerted the opposite effect. SPDEF may act through EPHA5, ZBTB46 and SASH1; SOX4 may act through MMP12 and HIVEP3. Conclusion: Epigenetics plays a role in IHs. SPDEF and SOX4 may act in IHs.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

Link

https://www.futuremedicine.com/doi/pdf/10.2217/epi-2020-0060

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