Radiologically isolated syndrome: targeting miRNAs as prognostic biomarkers-Reference-Cited by-同舟云学术

Radiologically isolated syndrome: targeting miRNAs as prognostic biomarkers

Published:2020-12 Issue:23 Volume:12 Page:2065-2076
ISSN:1750-1911
Container-title:Epigenomics
language:en
Short-container-title:Epigenomics

Author:

Muñoz-San Martín María¹^ORCID,Torras Sandra¹,Robles-Cedeño René²³⁴^ORCID,Buxó Maria⁵^ORCID,Gomez Imma¹,Matute-Blanch Clara⁶^ORCID,Comabella Manuel³⁶^ORCID,Villar Luisa María³⁷^ORCID,Perkal Héctor²,Quintana Ester¹³⁴^ORCID,Ramió-Torrentà Lluís²³⁴^ORCID

Affiliation:

1. Neurodegeneration & Neuroinflammation Group, Girona Biomedical Research Institute (IDIBGI), 17190 Salt, Spain

2. Department of Neurology, Girona Neuroimmunology & Multiple Sclerosis Unit, Dr. Josep Trueta University Hospital & Santa Caterina Hospital, Girona/Salt-Spain; Neurodegeneration & Neuroinflammation Group, Girona Biomedical Research Institute (IDIBGI), 17190 Salt, Spain

3. REEM, Red Española de Esclerosis Múltiple

4. Department of Medical Sciences, Faculty of Medicine, University of Girona, 17190 Girona, Spain

5. Girona Biomedical Research Institute (IDIBGI), 17190 Salt, Spain

6. Servei de Neurologia-Neuroimmunologia, Centre d’Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d’Hebron (VHIR), Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, 08035 Barcelona, Spain

7. Department of Immunology, Hospital Ramón y Cajal, IRYCIS, 28034 Madrid, Spain

Abstract

Aim: Some clinical and biological characteristics have been described as prognostic factors for clinical conversion into clinically definite multiple sclerosis in radiologically isolated syndrome (RIS) population. The aim of this study was to assess signatures of circulating miRNAs in those patients according to their conversion status after 5 years of follow-up. Patients & methods: OpenArray plates assessing 216 miRNA candidates were run in 15 RIS patients, and their relative abundances were analyzed. Results: A specific profile of deregulated circulating miRNAs (miR-144-3p, miR-448 and miR-653-3p in cerebrospinal fluid and miR-142-3p, miR-338-3p, miR-363-3p, miR-374b-5p, miR-424-5p, miR-483-3p in plasma) differentiated individuals who remained as RIS after 5 years of follow-up. Conclusion: Circulating miRNAs might be used as prognostic biomarkers for RIS patients.

Funder

Agència de Gestió d’Ajuts Universitaris i de Recerca

Fundación 2000

Instituto Carlos III – Spanish Government

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

Link

https://www.futuremedicine.com/doi/pdf/10.2217/epi-2020-0172

Reference43 articles.

1. Incidental MRI anomalies suggestive of multiple sclerosis: The radiologically isolated syndrome