Prognostic value of the miRNA-27a and PPAR/RXRα signaling axis in patients with thyroid carcinoma-Reference-Cited by-同舟云学术

Prognostic value of the miRNA-27a and PPAR/RXRα signaling axis in patients with thyroid carcinoma

Published:2020-10 Issue:20 Volume:12 Page:1825-1843
ISSN:1750-1911
Container-title:Epigenomics
language:en
Short-container-title:Epigenomics

Author:

Toraih Eman A¹²^ORCID,Fawzy Manal S³⁴^ORCID,Abushouk Abdelrahman I⁵^ORCID,Shaheen Sameerah⁶^ORCID,Hobani Yahya H⁷^ORCID,Alruwetei Abdulmohsen M⁸^ORCID,A Mansouri Omniah⁹^ORCID,Kandil Emad¹⁰^ORCID,Badran Dahlia I³^ORCID

Affiliation:

1. Department of Surgery, Tulane University, School of Medicine, New Orleans, LA 70112, USA

2. Department of Histology & Cell Biology, Genetics Unit, Faculty of Medicine, Suez Canal University, Ismailia 41522, Egypt

3. Department of Medical Biochemistry & Molecular Biology, Faculty of Medicine, Suez Canal University, Ismailia 41522, Egypt

4. Department of Biochemistry, Faculty of Medicine, Northern Border University, Arar 1321, Saudi Arabia

5. Faculty of Medicine, Ain Shams University, Cairo 11591, Egypt

6. Department of Anatomy & Stem Cell Unit, College of Medicine, King Saud University, Riyadh 11362, Saudi Arabia

7. Medical Laboratory Technology, College of Applied Medical Sciences, Jazan University, Jazan 45142, KSA

8. Department of Medical Laboratory, College of Applied Medical Sciences, Qassim University, Qassim 51452, Saudi Arabia

9. Department of Biology, University of Jeddah, College of Science, Jeddah, 21959, Saudi Arabia

10. Department of Surgery, Division of Endocrine & Oncologic Surgery, Tulane University School of Medicine, New Orleans, LA 70112, USA

Abstract

The authors aimed to evaluate the prognostic value of miRNA-27a (miR-27a), peroxisome proliferator-activated receptor alpha/gamma ( PPARα/γ) and retinoid X receptor alpha (RXRα) tissue expression in patients with thyroid carcinoma. The expression levels were quantified in 174 archived thyroid specimens using real-time quantitative PCR. Downregulation of miR-27a was associated with lymph node stage and multifocality. PPARα expression was associated with histopathological type, tumor size and lymph node invasion. Moreover, RXRα expression was lower in patients who underwent total/subtotal thyroidectomy or received radioactive iodine treatment. Patients with upregulated miR-27a and downregulated RXRα showed a higher frequency of advanced lymph node stage and relapse by cluster analysis. Both miR-27a and PPARα/RXRα showed association with different poor prognostic indices in thyroid cancer patients.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

Link

https://www.futuremedicine.com/doi/pdf/10.2217/epi-2020-0167

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