Identification of tRNA-derived fragments and their potential roles in diabetic cataract rats-Reference-Cited by-同舟云学术

Identification of tRNA-derived fragments and their potential roles in diabetic cataract rats

Published:2020-08 Issue:16 Volume:12 Page:1405-1418
ISSN:1750-1911
Container-title:Epigenomics
language:en
Short-container-title:Epigenomics

Author:

Han Xiaoyan¹²³⁴^ORCID,Cai Lei¹²³⁴^ORCID,Lu Yi¹²³⁴^ORCID,Li Dan¹²³⁴⁵^ORCID,Yang Jin¹²³⁴^ORCID

Affiliation:

1. Department of Ophthalmology & the Eye Institute, Eye & Ear, Nose, & Throat Hospital, Fudan University, Shanghai 200031, PR China

2. The Key Laboratory of Myopia, Ministry of Health, Shanghai 200031, PR China

3. Shanghai Key Laboratory of Visual Impairment & Restoration, Shanghai 200031, PR China

4. Visual Rehabilitation Professional Committee, Chinese Association of Rehabilitation Medicine, Shanghai 200031, PR China

5. State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 200031, PR China

Abstract

Aim: To illustrate the expression profile of transfer RNA-derived fragments and reveal their putative role in the pathogenesis of diabetic cataract (DC) rats. Materials & methods: Small RNA sequencing was conducted in the lens epithelium of rats lens. The data were validated by quantitative real-time PCR, and bioinformatic analysis was performed to explore the roles of the fragments in DC pathogenesis. Results: A total of 213 differentially expressed tRNA-related fragments were identified, in which 111 were upregulated and 102 were downregulated in DC rats. Bioinformatics analysis revealed that several associated pathways might participate in the development of DC rats. Conclusion: tRNA-derived fragments may be involved in the pathogenesis of DC rats.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

Link

https://www.futuremedicine.com/doi/pdf/10.2217/epi-2020-0193

Reference35 articles.

1. The global state of cataract blindness

2. Cataract Surgery in Patients with Diabetes: Management Strategies

3. Diabetic Cataract—Pathogenesis, Epidemiology and Treatment

4. LncRNA MALAT1 promotes the apoptosis and oxidative stress of human lens epithelial cells via p38MAPK pathway in diabetic cataract

5. MiR-30a inhibits BECN1-mediated autophagy in diabetic cataract

Cited by 13 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Novel insights into transfer RNA-derived small RNA (tsRNA) in cardio-metabolic diseases;Life Sciences;2024-02

2. Identification and clinical significance of tsRNAs and miRNAs in PBMCs of treatment-requiring retinopathy of prematurity;Experimental Eye Research;2023-07

3. Plasma tRF-16-79MP9PD and tRF-28-OB1690PQR304 as potential biomarkers for 4- to 7-year-old children with obstructive sleep apnea-hypopnea syndrome;Frontiers in Pediatrics;2023-05-30

4. The emerging roles of tRNAs and tRNA-derived fragments during aging: Lessons from studies on model organisms;Ageing Research Reviews;2023-03

5. Identification of tRNA-derived small RNAs expression profiles and their potential functions in age-related cataract;2023-02-10