Exosomal microRNAs: novel players in cervical cancer

Author:

Nahand Javid Sadri12,Vandchali Noushin Rezaei3,Darabi Hassan4,Doroudian Mohammad5,Banafshe Hamid Reza6,Moghoofei Mohsen7,Babaei Farhad7,Salmaninejad Arash89,Mirzaei Hamed10ORCID

Affiliation:

1. Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran

2. Student Research Committee, Iran University of Medical Sciences, Tehran, Iran

3. Department of Biochemistry & Genetic, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran

4. Medical Genetics Research Center, Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

5. Department of Cell & Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran

6. Department of Pharmacology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran.

7. Department of Microbiology, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

8. Drug Applied Research Center, Student Research Committee, Tabriz University of Medical Science, Tabriz, Iran

9. Department of Medical Genetics, Faculty of Medicine, Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran

10. Research Center for Biochemistry & Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran

Abstract

Cervical cancer ranks fourth for both mortality and morbidity in women globally. Exosomes are considered as extracellular vesicles, secreted continuously by many cells with a size range from 30 to 150 nm. Exosomes can encapsulate microRNAs (miRNAs) and release them for cellular communications. This exosome-induced miRNA transfer is a novel strategy for genetic exchange among cells. This trafficking modality affects many pathological as well as physiological conditions. Moreover, exosomes can protect the miRNAs against harsh environments and keep them very stable. Given that a variety of exosomal miRNAs derived from cervical cancer cells can be targeted to recipient cells and contribute to tumorgenesis, it has been documented that exosomal miRNAs could be applied as diagnostic and therapeutic biomarkers in the treatment of cervical cancer. Herein, we summarize the pathologic and diagnostic roles of exosomal miRNAs in the cervical cancer. Moreover, we highlight the roles of exosomal miRNAs in other cancers.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

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