Maternal anxiety and depression in pregnancy and DNA methylation of the NR3C1 glucocorticoid receptor gene-Reference-Cited by-同舟云学术

Maternal anxiety and depression in pregnancy and DNA methylation of the NR3C1 glucocorticoid receptor gene

Published:2021-11 Issue:21 Volume:13 Page:1701-1709
ISSN:1750-1911
Container-title:Epigenomics
language:en
Short-container-title:Epigenomics

Author:

Dereix Alexandra E¹,Ledyard Rachel²,Redhunt Allyson M³,Bloomquist Tessa R⁴,Brennan Kasey JM⁴,Baccarelli Andrea A⁴,Hacker Michele R³⁵⁶,Burris Heather H²⁷⁸^ORCID

Affiliation:

1. Stritch School of Medicine, Loyola University Chicago, Chicago, IL 60153, USA

2. Division of Neonatology, Children’s Hospital of Pennsylvania, Philadelphia, PA 19104, USA

3. Department of Obstetrics & Gynecology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA

4. Department of Environmental Health Sciences, Columbia University Mailman School of Public Health Environmental Health Sciences, New York, NY 10032, USA

5. Department of Obstetrics, Gynecology & Reproductive Biology, Harvard Medical School, Boston, MA 02115, USA

6. Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA 02115, USA

7. Division of Neonatology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA

8. Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA

Abstract

Aim: To quantify associations of anxiety and depression during pregnancy with differential cord blood DNA methylation of the glucorticoid receptor ( NR3C1). Materials & methods: Pregnancy anxiety, trait anxiety and depressive symptoms were collected using the Pregnancy Related Anxiety Scale, State-Trait Anxiety Index and Edinburgh Postnatal Depression Scale, respectively. NR3C1 methylation was determined at four methylation sites. Results: DNA methylation of CpG1 in the NR3C1 CpG island shore was higher in infants born to women with high pregnancy anxiety (β 2.54, 95% CI: 0.49–4.58) and trait anxiety (β 1.68, 95% CI: 0.14–3.22). No significant association was found between depressive symptoms and NR3C1 methylation. Conclusion: We found that maternal anxiety was associated with increased NR3C1 CpG island shore methylation.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

Link

https://www.futuremedicine.com/doi/pdf/10.2217/epi-2020-0022

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