Essential role of CD4+ T cells for the activation of group 2 innate lymphoid cells during respiratory syncytial virus infection in mice-Reference-Cited by-同舟云学术

Essential role of CD4+ T cells for the activation of group 2 innate lymphoid cells during respiratory syncytial virus infection in mice

Published:2019-10 Issue:15 Volume:11 Page:1303-1313
ISSN:1750-743X
Container-title:Immunotherapy
language:en
Short-container-title:Immunotherapy

Author:

Han Xu¹²,Bai Song¹,Cui Yulin¹,Zhu Wenwen¹,Zhao Na¹,Liu Beixing¹

Affiliation:

1. Department of Pathogenic Biology, School of Basic Medical Science, China Medical University, Shenyang, China

2. Department of Medical Oncology, The First Affiliated Hospital of China Medical University, Shenyang, China

Abstract

Aim: To investigate whether and how CD4+ T cells contribute to ILC2 activation during respiratory syncytial virus (RSV) infection. Methods: The methods of flow cytometry, quantitative PCR and ELISA were used in the present study. Results: Depletion of CD4+ T cells diminished the numbers of lung ILC2s as well as their ability to produce type 2 cytokines. CD4+ T cell-mediated ILC2 activation is related to IL-2. The main cellular source of IL-2 was CD4+ T cells. Depletion of CD4+ T cells decreased IL-2 levels in the lungs of RSV-infected mice. IL-2 can directly stimulate ILC2 proliferation and promote ILC2s to produce cytokines. Treatment of mice with neutralizing anti-IL-2 monoclonal antibodies diminished ILC2 activation. Conclusion: These results suggest that CD4+ T cells contribute to RSV-induced ILC2 activation partly via producing IL-2.

Publisher

Future Medicine Ltd

Subject

Oncology,Immunology,Immunology and Allergy

Link

https://www.futuremedicine.com/doi/pdf/10.2217/imt-2019-0084

Reference33 articles.

1. Biology of Lung Dendritic Cells at the Origin of Asthma

2. The many paths to asthma: phenotype shaped by innate and adaptive immunity

3. Respiratory syncytial virus infection results in airway hyperresponsiveness and enhanced airway sensitization to allergen.

4. Respiratory viral infections as promoters of allergic sensitization and asthma in animal models

5. Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years

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