Characterization of unrelated clinical Legionella pneumophila isolates in Catalonia by monoclonal subgrouping and sequence-based typing-Reference-Cited by-同舟云学术

Characterization of unrelated clinical Legionella pneumophila isolates in Catalonia by monoclonal subgrouping and sequence-based typing

Published:2016-07 Issue:7 Volume:11 Page:865-875
ISSN:1746-0913
Container-title:Future Microbiology
language:en
Short-container-title:Future Microbiology

Author:

Garcia-Nuñez Marian¹²³,Quero Sara¹²³,Pedro-Botet Maria Lluisa¹²³,Barrabeig Irene⁴,Avarez Josep⁴,Campoy Irene¹,Sala Maria Rosa⁴,Parraga-Niño Noemí¹²³,Minguell Sofia⁴,Caylà Joan⁴⁵,Mateu Lourdes¹²³,Sabria Miquel¹²³

Affiliation:

1. Infectious Diseases Unit, Fundació Institut d'Investigació Germans Trias i Pujol, Hospital Germans Trias i Pujol, Badalona, Spain E-08916

2. Grupo de estudio de la Legionelosis, Autonomous University of Barcelona, Cerdanyola, Spain E-08913

3. Ciber de Enfermedades Respiratorias, Madrid, Spain E-28029

4. Epidemiological Surveillance, Publich Health Agency of Catalonia, Barcelona, Spain E-08005

5. Ciber de Salud Publica, Madrid, Spain, E-28029

Abstract

Aim: To characterize the genetic diversity of unrelated Legionella pneumophila clinical isolates in Catalonia and compare with other European regions. Methods: 95 unrelated isolates were analyzed using monoclonal antibodies and sequence-based typing, 1989–2013. Results: The isolates showed a high diversity (IOD 0.964) with a predominance of some profiles (ST37-Phialdelphia, ST23-Philadelphia and ST1-OLDA). All regions had predominant sequence types (STs) that differed between regions, and only 3% of STs were shared between the three regions. Conclusion: L. pneumophila clinical isolates from Catalonia presented a high diversity and can be used in epidemiological surveillance studies. The heterogeneous predominance of STs between European regions suggested a relationship between geographical distribution and virulence of some STs.

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fmb-2016-0013

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