The cost of treating mucormycosis with isavuconazole compared with standard therapy in the UK

Author:

Bagshaw Emma1,Kuessner Daniel2,Posthumus Jan2,Escrig Cesar3,Blackney Michael1,Heimann Sebastian Marcel4,Cornely Oliver Andreas45

Affiliation:

1. Covance Market Access, Covance, London, UK

2. Global Market Access and Health Economics, Basilea Pharmaceutica International Ltd, Basel, Switzerland

3. Global Medical Affairs, Basilea Pharmaceutica International Ltd, Basel, Switzerland

4. Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany

5. Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Clinical Trials Centre Cologne (ZKS Köln), University of Cologne, Cologne, Germany

Abstract

Aim: Mucormycosis is a fungal infection associated with high mortality. Until recently, the only licensed treatments were amphotericin B (AMB) formulations. Isavuconazole (ISAV) is a new mucormycosis treatment. A UK-based economic model explored treatment costs with ISAV versus liposomal AMB followed by posaconazole. Materials & methods: As a matched case–control analysis showed similar efficacy for ISAV and AMB, a cost-minimization approach was taken. Direct costs – drug acquisition, monitoring and administration, and hospitalization costs – were estimated from the National Health Service perspective. Results: Per-patient costs for ISAV and liposomal AMB + posaconazole were UK£26,810 and UK£41,855, respectively, with savings primarily driven by drug acquisition and hospitalization costs. Conclusion: ISAV may reduce costs compared with standard mucormycosis therapy.

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

Reference37 articles.

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