Long-term effectiveness of levodopa–carbidopa intestinal gel in 177 Spanish patients with advanced Parkinson's disease

Author:

Valldeoriola Francesc1,Grandas Francisco2,Santos-García Diego3,Regidor Ignacio4,Catalán María José5,Arbelo José Matías6,Puente Víctor7,Mir Pablo89,Parra Juan Carlos10

Affiliation:

1. Movement Disorders Unit, Neurology Department, Hospital Clínic, Carrer Villarroel, 170, 08036 Barcelona, Spain

2. Neurology Department, Hospital General Universitario Gregorio Marañón, Calle del Doctor Esquerdo 46, 28007 Madrid, Spain

3. Neurology Section, Internal Medicine Department, Hospital Arquitecto Marcide, Complejo Hospitalario Universitario de Ferrol (CHUF), Av. Residencia s/n, 15405 Ferrol, A Coruña, Spain

4. Functional Neurosugery Unit, Hospital Universitario Ramón y Cajal, Carretera Colmenar km 9,100, 28034 Madrid, Spain

5. Neurology Department, Hospital Clínico San Carlos, Profesor Martín Lagos, S/N, 28040 Madrid, Spain

6. Neurology Department, Hospital Universitario Insular de Gran Canaria, Avenida Marítima del Sur, s/n, 35016 Las Palmas de Gran Canaria, Spain

7. Movement Disorders Unit, Neurology Department, Parc de Salut Mar, Institut Municipal d'Investigació Medica Hospital del Mar, Universitat Autònoma de Barcelona, Passeig Marítim, 25–29, 08003 Barcelona, Spain

8. Movement Disorders Unit, Neurology Department, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Av. Manuel Siurot, s/n, 41013 Sevilla, Spain

9. Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Campus de Cantoblanco, 28049 Madrid, Spain

10. AbbVie Spain S.L.U. Avenida De Burgos 91, 28050 Madrid, Spain

Abstract

Aim: To assess long-term effectiveness and tolerability of levodopa–carbidopa intestinal gel (LCIG) in Spanish patients with advanced Parkinson's disease. Patients & methods: This was an observational, multicenter, cross-sectional, retrospective study. Results: Data of 177 patients were analyzed. LCIG treatment led to a reduction in the percentage of daily ‘off’ time (16.2 vs 47.6% before LCIG), an increase in the percentage of daily ‘on’ time without disabling dyskinesia (55.6 vs 21.6%). Most patients experienced improvements in freezing of gait, tremor, dizziness, fatigue or flat mood. Adverse events related to levodopa, gastrostomy and technical issues were reported in 36.2, 42.4 and 43.5% of patients, respectively. Conclusion: This study confirms the long-term effectiveness and safety profile of LCIG in patients with advanced Parkinson's disease.

Publisher

Future Medicine Ltd

Subject

Neurology (clinical)

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