Molecular pathogenesis of hereditary lung cancer: a literature review

Author:

Rammal Souraya1,Kourie Hampig Raphael2,Jalkh Nadine3,Mehawej Cybel3,Chouery Eliane3,Moujaess Elissar2ORCID,Dabar Georges4

Affiliation:

1. Faculty of Medicine, Saint Joseph University of Beirut, Beirut, Lebanon

2. Hematology-Oncology Department, Faculty of Medicine, Saint Joseph University of Beirut, Beirut, Lebanon

3. Medical Genetics Unit, Faculty of Medicine, Saint Joseph University of Beirut, Beirut, Lebanon

4. Pulmonary & Critical Care Division, Hotel Dieu de France, Saint Joseph University of Beirut, Beirut, Lebanon

Abstract

Among all cancer types, pulmonary cancer has the highest mortality rate. Tobacco consumption remains the major risk factor for the development of lung cancer. However, many studies revealed a correlation between inherited genetic variants and predisposition to lung cancer, especially in nonsmokers. To date, genetic testing for the detection of germline mutations is not yet recommended in patients with lung cancer and testing is focused on somatic alterations given their implication in the treatment choice. Understanding the impact of genetic predisposition on the occurrence of lung cancer is essential to enable the introduction of accurate guidelines and recommendations that might reduce mortality. In this review paper, we describe familial lung cancer, and expose germline mutations that are linked to this type of cancer. We also report pathogenic genetic variants linked to syndromes associated with lung cancer.

Publisher

Future Medicine Ltd

Subject

Pharmacology,Genetics,Molecular Medicine

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