Genetic variability of CYP2D6, CYP3A4 and CYP3A5 among the Egyptian population

Author:

Mutawi Thuraya M1ORCID,Zedan Mohamed M2ORCID,Yahya Raida S1ORCID,Zakria Mahmoud M3ORCID,El-Sawi Mamdouh R4ORCID,Gaedigk Andrea5ORCID

Affiliation:

1. Department of Laboratories, Children Hospital, Faculty of Medicine, Mansoura University, Mansoura, 35516, Egypt

2. Department of Pediatrics, Faculty of Medicine, Mansoura University, Mansoura, 35516, Egypt

3. The Urology & Nephrology Center, Faculty of Science, Mansoura University, Mansoura, 35516, Egypt

4. Physiology Division, Zoology Department, Faculty of Science, Mansoura University, Mansoura, 35516, Egypt

5. Division of Clinical Pharmacology, Toxicology & Therapeutic Innovation, Children's Mercy Kansas City & School of Medicine, University of Missouri-Kansas City, Kansas City, MO 64108, USA

Abstract

Aim: This study investigated major allelic variants of CYP2D6, CYP3A4 and CYP3A5 in Egyptians, an Arabic population for which there is little information regarding these important pharmacogenes. Patients & methods: CYP2D6*2, *4, *5, *10, *41 and gene copy number variation, as well as CYP3A4*22 and CYP3A5*3 were determined with commercially available TaqMan assays in 145 healthy study participants. Results: The CYP2D6 alleles identified suggest that the prevalence of poor metabolizers is low as none were found among the 145 subjects investigated. The frequency for CYP3A5 nonexpressers was 74.5% and the CYP3A4*22 allele frequency was low at 2.0%. Conclusion: These preliminary findings indicate that pharmacogene variation in Egyptians is different from those of other Middle Eastern/Arabic populations and warrants further investigation.

Funder

The Post Graduate Studies, Research and Cultural Affairs, Mansoura University

Publisher

Future Medicine Ltd

Subject

Pharmacology,Genetics,Molecular Medicine

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