LRP1 polymorphisms associated with warfarin stable dose in Chinese patients: a stepwise conditional analysis-Reference-Cited by-同舟云学术

LRP1 polymorphisms associated with warfarin stable dose in Chinese patients: a stepwise conditional analysis

Published:2020-11 Issue:16 Volume:21 Page:1169-1178
ISSN:1462-2416
Container-title:Pharmacogenomics
language:en
Short-container-title:Pharmacogenomics

Author:

Li Dan¹²³,Zhu Hong⁴,Luo Zhi-Ying⁵,Chen Yi¹²³,Song Guo-Bao⁶,Zhou Xin-Ming⁶,Yan Han⁵,Zhou Hong-Hao¹²⁷³^ORCID,Zhang Wei¹²⁷³^ORCID,Li Xi¹²⁷³^ORCID

Affiliation:

1. Department of Clinical Pharmacology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, PR China

2. Department of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, PR China

3. Institute of Clinical Pharmacology, Central South University; Hunan Key Laboratory of Pharmacogenetics, Changsha, 410078, PR China

4. Department of Cardiovascular Surgery, Xiangya Hospital, Central South University, Changsha, 410008, PR China

5. Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, PR China

6. Department of Cardio-Thoracic Surgery, the Second Xiangya Hospital, Central South University, Changsha, 410011, PR China

7. Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, PR China

Abstract

Aim: The aim of this study was to investigate whether variability in warfarin stable dose (WSD) could be influenced by vitamin K-related polymorphisms in patients with heart valve replacement. Patients & methods: Twenty-nine vitamin K-related SNPs in 208 patients who initially took warfarin and achieved WSD were genotyped. Results: After conducting conditional analysis for both VKORC1 -1639G>A and CYP2C9*3, LRP1 rs1800139 and LRP1 rs1800154 were significantly associated with WSD (p = 0.007 and p = 0.015, respectively). Multivariate analysis showed that LRP1 rs1800139 accounted for 5.9% WSD variability. Conclusion: Our results suggest that a novel vitamin K-related gene, LRP1, exerts a relevant influence on WSD, independent of VKORC1 -1639G>A and CYP2C9*3.

Funder

Natural Science Foundation of Hunan Province

National key research and development program

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities of Central South University

Publisher

Future Medicine Ltd

Subject

Pharmacology,Genetics,Molecular Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/pgs-2020-0004

Reference41 articles.