Aripiprazole for irritability associated with autistic disorder in children and adolescents aged 6

Aripiprazole for irritability associated with autistic disorder in children and adolescents aged 6–17 years

Published:2010-08 Issue:4 Volume:4 Page:375-381
ISSN:1745-5111
Container-title:Pediatric Health
language:en
Short-container-title:Pediatric Health

Author:

Blankenship Kelly¹²,Erickson Craig A¹²,Stigler Kimberly A¹²,Posey David J¹²,McDougle Christopher J

Affiliation:

1. Christian Sarkine Autism Treatment Center, James Whitcomb Riley Hospital for Children, IN, USA

2. Department of Psychiatry, Indiana University School of Medicine, 702 Barnhill Drive, ROC 4300, Indianapolis, IN 46202, USA

Abstract

Aripiprazole was recently US FDA-approved to treat irritability in children and adolescents with autistic disorder aged 6–17 years. There are currently only two psychotropics approved by the FDA to treat irritability in the autistic population. This drug profile will discuss available studies of aripiprazole in individuals with pervasive developmental disorders, two of which led to its recent FDA approval. We will discuss the efficacy, as well as the safety and tolerability of the drug documented in these studies. In addition, the chemistry, pharmacokinetics, metabolism and mechanism of action of aripiprazole will be reviewed.

Publisher

Future Medicine Ltd

Subject

Pediatrics,Pediatrics, Perinatology and Child Health

Link

https://www.futuremedicine.com/doi/pdf/10.2217/phe.10.45

Reference26 articles.

1. Diagnostic and Statistical Manual of Mental Disorders. 4th Edition, Text Revision.American Psychiatric Association, Washington, DC, USA69–84 (2000).

2. Risperidone in pervasive developmental disorders

3. HollanderE, Anagnostou E:Clinical Manual for the Treatment of Autism.American Psychiatric Publishing, Inc., Washington, DC, USA99–120 (2007).

4. A Comparison of Haloperidol and Behavior Therapy and Their Interaction in Autistic Children

Cited by 45 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The Frequency of CYP2D6 and CYP3A4/5 Genotypes and The Impact of Their Allele Translation and Phenoconversion-Predicted Enzyme Activity on Risperidone Pharmacokinetics in Saudi Children with Autism;Biochemical Genetics;2023-12-02

2. Taurine as a potential therapeutic agent interacting with multiple signaling pathways implicated in autism spectrum disorder (ASD): An in-silico analysis;IBRO Neuroscience Reports;2023-12

3. Off-label psychopharmacological interventions for autism spectrum disorders: strategic pathways for clinicians;CNS Spectrums;2023-08-04

4. Buspirone in Autism Spectrum Disorder: A Systematic Review;Cureus;2023-05-21

5. MANAGEMENT OF AUTISM SPECTRUM DISORDER: A PILOT STUDY IN SAUDI PAEDIATRICS;Military Medical Science Letters;2023-03-29