Clinical outcomes in octogenarians treated with docetaxel as first-line chemotherapy for castration-resistant prostate cancer

Author:

Veccia Antonello1,Caffo Orazio1,De Giorgi Ugo2,Di Lorenzo Giuseppe3,Ortega Cinzia4,Scognamiglio Florinda5,Aieta Michele6,Facchini Gaetano7,Mansueto Giovanni8,Mattioli Rodolfo9,Procopio Giuseppe10,Zagonel Vittorina11,D'Angelo Alessandro12,Spizzo Gilbert13,Bortolus Roberto14,Donini Maddalena15,Lo Re Giovanni16,Massari Francesco17,Vicario Giovanni18,Zucali Paolo A19,Alesini Daniele20,Bonetti Andrea21,Mucciarini Claudia22,Nicodemo Maurizio23,Berruti Alfredo24,Fratino Lucia25,Lodde Michele26,Messina Caterina27,Perin Alessandra28,Santini Daniele29,Sava Teodoro30,Tucci Marcello31,Basso Umberto11,Maines Francesca1,Burgio Luca S2,Galligioni Enzo1

Affiliation:

1. Medical Oncology Department, Santa Chiara Hospital, Largo Medaglie d'Oro, 38100 Trento, Italy

2. Medical Oncology Department, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Via Piero Maroncelli 40, 47014 Meldola, Italy

3. Oncologia Urologica, Azienda Ospedaliera Universitaria “Federico II”, Via S. Pansini 5, 80131 Napoli, Italy

4. Medical Oncology Department, Institute for Cancer Research & Treatment, Strada Provinciale 142, Km 3.95, 10060 Candiolo, Italy

5. Medical Oncology Department, Cardarelli Hospital, Via A. Cardarelli 9, 80131 Napoli, Italy

6. Medical Oncology Department, Referral Cancer Center of Basilicata – IRCCS, Via Padre Pio, 1, 85028 Rionero in Vulture, Italy

7. Division of Medical Oncology, Department of Uro-Gynaecological Oncology, Istituto Nazionale Tumori “Fondazione G. Pascale” – IRCCS, Via Mariano Semmola, 80131 Naples, Italy

8. Medical Oncology Department, General Hospital, Via Fabi, 03100 Frosinone, Italy

9. Medical Oncology Department, Santa Croce Hospital, Viale Vittorio Veneto 2, 61032 Fano, Italy

10. Oncologia medica genitourinaria – Fondazione Istituto Nazionale Tumori, Via Venezian 1, 20133 Milan, Italy

11. Medical Oncology Unit 1, Istituto Oncologico Veneto IOV – IRCCS, Via Gattamelata 64, 35128 Padua, Italy

12. Medical Oncology Department, San Vincenzo Hospital, Via Sirina, 98039 Taormina, Italy

13. Medical Oncology Department, General Hospital, Via Rossini, 5, 39012 Merano, Italy

14. Radiation Oncology Department, National Cancer Institute, Via Franco Gallini, 2, 33081 Aviano, Italy

15. Medical Oncology Department, Istituti Ospitalieri, Viale Concordia 1, 26100 Cremona, Italy

16. Medical Oncology Department, Santa Maria degli Angeli Hospital, Via Montereale 24, 33170 Pordenone, Italy

17. Medical Oncology, Azienda Ospedaliera Universitaria Integrata, University of Verona, Piazzale A. Scuro 10, 37134 Verona, Italy

18. Medical Oncology Department, San Giacomo Apostolo Hospital, Via dei Carpani 16/Z, 31033 Castelfranco Veneto, Italy

19. Department of Medical Oncology & Haematology, Humanitas Clinical & Research Center, Via Manzoni, 56, 20089 Rozzano, Italy

20. Department of Radiological, Oncological & Anatomopathological Sciences, La Sapienza, University of Rome, Piazzale Aldo Moro, 5, 00185 Rome, Italy

21. Medical Oncology Department, Mater Salutis Hospital, Via Gianella, 1, 37045 Legnago, Italy

22. Medical Oncology Department, Ramazzini Hospital, Via Guido Molinari, 2, 41012 Carpi, Italy

23. Medical Oncology Department, Sacro Cuore Don Calabria Hospital, Via don A. Sempreboni, 5, 37024 Negrar, Italy

24. Medical Oncology Department, Spedali Civili Hospital, P.le Spedali Civili, 1, 25123 Brescia, Italy

25. Medical Oncology Department, National Cancer Institute, Via Franco Gallini, 2, 33081 Aviano, Italy

26. Urology Department, General Hospital, Via Böhler 5, 39100 Bolzano, Italy

27. Medical Oncology Department, Papa Giovanni XXIII Hospital, Piazza OMS 1, 24127 Bergamo, Italy

28. Medical Oncology Department, General Hospital, via Garziere n. 42, 36014 Santorso, Italy

29. Medical Oncology Department, University Campus Bio-Medico, Via Álvaro del Portillo, 00128 Rome, Italy

30. Medical Oncology Department, General Hospital, P.le A. Stefani 1, 37126 Verona, Italy

31. Medical Oncology Department, University of Torino, San Luigi Hospital, Regione Gonzole, 10, 10043 Orbassano, Italy

Abstract

Aim: To assess clinical outcomes in octogenarians treated with docetaxel (DOC) for metastatic castration-resistant prostate cancer. Patients & methods: The multicenter retrospective study was based on a review of the pre- and post-DOC clinical history, DOC treatment and outcomes. Results: We reviewed the records of 123 patients (median age: 82 years) who received DOC every 3 weeks or weekly, without significant grade 3–4 toxicities. Median progression-free survival was 7 months; median overall survival from the start of DOC was 20 months, but post-progression treatments significantly prolonged overall survival. Conclusion: The findings of this study suggest that toxicity is acceptable, survival is independent of patient's age and survival can be significantly prolonged by the use of new agents.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

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