Lgr5 expression, cancer stem cells and pancreatic cancer: results from biological and computational analyses-Reference-Cited by-同舟云学术

Lgr5 expression, cancer stem cells and pancreatic cancer: results from biological and computational analyses

Published:2015-04 Issue:7 Volume:11 Page:1037-1045
ISSN:1479-6694
Container-title:Future Oncology
language:en
Short-container-title:Future Oncology

Author:

Andrikou Kalliopi¹,Santoni Matteo¹,Piva Francesco²,Bittoni Alessandro¹,Lanese Andrea¹,Pellei Chiara¹,Conti Alessandro³,Loretelli Cristian¹,Mandolesi Alessandra⁴,Giulietti Matteo²,Scarpelli Marina⁴,Principato Giovanni²,Falconi Massimo⁵,Cascinu Stefano¹

Affiliation:

1. Medical Oncology, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Via Conca 71, 60126 Ancona, Italy

2. Department of Clinical Sciences, Polytechnic University of the Marche Region, Piazza Roma 22, 60121 Ancona, Italy

3. Section of Urology, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Via Conca 71, 60126 Ancona, Italy

4. Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Via Conca 71, 60126 Ancona, Italy

5. Pancreatic Surgery Unit, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Via Conca 71, 60126 Ancona, Italy

Abstract

ABSTRACT Aims: To determine the relationship between Lgr5 and other stemness markers and pathologic features in pancreatic ductal adenocarcinoma (PDAC) samples. Materials & methods: In 69 samples, Lgr5 was analyzed by qRT-PCR together with a panel of 29 genes. Bioinformatic analysis was carried out to identify a possible pathway regulating Lgr5 expression in PDAC. Results: Lgr5 expression was not associated with the expression of tested cancer stem cell markers. Moreover, it was not an independent predictor of survival neither at univariate analysis (p = 0.21) nor at multivariate analysis (p = 0.225). Conclusion: Based on the lack of correlation between Lgr5 and tested cancer stem cell markers, Lgr5 does not seem to be a potential stemness marker or prognostic factor in PDAC.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fon.15.27

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