Affiliation:
1. Clinical Oncology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
2. Medical Microbiology & Immunology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Abstract
Background: We performed a meta-analysis of the risk of endocrine adverse events associated with immune check point inhibitors. Methods: Eligible studies included randomized trials of cancer patients on immune checkpoint inhibitors; describing events of hypothyroidism, hyperthyroidism, hypophysitis and adrenal insufficiency. Results: A total of ten clinical trials were eligible for the meta-analysis. The relative risk of all-grade hypothyroidism, hyperthyroidism, hypophyisitis and adrenal insufficiency were 8.26 (95% CI: 4.67–14.62; p < 0.00001), 5.48 (95% CI: 1.33–22.53; p = 0.02); 22.03 (95% CI: 8.52–56.94; p < 0.00001), 3.87 (95% CI: 1.12–13.41; p = 0.03), respectively. Conclusion: Our meta-analysis has demonstrated that the use of immune check point inhibitors is associated with an increased risk of hypothyroidism, hyperthyroidism, hypophysitis and adrenal insufficiency compared with control.
Subject
Cancer Research,Oncology,General Medicine
Cited by
127 articles.
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