FBLN-3 as a biomarker of pleural plaques in workers occupationally exposed to carcinogenic fibers: a pilot study

Author:

Rapisarda Venerando1,Ledda Caterina1,Migliore Marcello2,Salemi Rossella3,Musumeci Andrea4,Bracci Massimo5,Marconi Andrea1,Loreto Carla6,Libra Massimo3

Affiliation:

1. Section of Occupational Medicine, Department of Clinical & Experimental Medicine, University of Catania, Catania, Italy

2. Academic Thoracic Surgery Unit, University Hospital ‘Policlinico-Vittorio Emanuele’, Department of Surgery, University of Catania, Catania, Italy

3. Section of Clinical & General Pathology & Oncology, Department of Biomedical & Biotechnological Sciences, University of Catania, Catania, Italy

4. Division of Radiology, University Hospital ‘Policlinico – Vittorio Emanuele’, Catania, Italy

5. Section of Occupational Medicine, Department of Clinical & Molecular Sciences, Polytechnic University of Marche, Ancona, Italy

6. Section of Anatomy & Histology, Department of Biomedical & Biotechnological Sciences, University of Catania, Catania, Italy

Abstract

FBLN-3 has recently been proposed as a biomarker for malignant mesothelioma. A significantly increased standardized mortality rate from malignant mesothelioma has been reported in Biancavilla, Italy. Its cause has been identified in environmental exposure to fluoro-edenite. The aim of this study was to seek a correlation between plasma FBLN-3 concentration and pleural plaques in subjects exposed to fluoro-edenite and in a nonexposed control group. Pleural plaques was never detected in the control group, whereas it was found in 52% of exposed subjects. Median FBLN-3 concentrations were 12.96 and 5.29 ng/ml in the exposed and the control group, respectively (p < 0.001). FBLN-3 plasma levels exhibited a high predictive value for the presence of pleural plaques.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3