IL-1B rs1143623 and EEF1A1P11-RPL7P9 rs10783050 polymorphisms affect the glucose-lowing efficacy of metformin in Chinese overweight or obese Type 2 diabetes mellitus patients-Reference-Cited by-同舟云学术

IL-1B rs1143623 and EEF1A1P11-RPL7P9 rs10783050 polymorphisms affect the glucose-lowing efficacy of metformin in Chinese overweight or obese Type 2 diabetes mellitus patients

Published:2015-09 Issue:14 Volume:16 Page:1621-1629
ISSN:1462-2416
Container-title:Pharmacogenomics
language:en
Short-container-title:Pharmacogenomics

Author:

Xiao Di¹²³,Zhang Si-Min⁴,Li Xi¹²³,Yin Ji-Ye¹²³,Gong Wei-Jing¹²,Zheng Yi⁵,Xu Xiao-Jing¹²,Lin Xu⁶,Ji Li-Nong⁴,Liu Rang-Ru¹²,Tang Qiang⁷,Zhang Wei¹²³,Zhou Hong-Hao¹²³,Han Xue-Yao⁴,Liu Zhao-Qian¹²³

Affiliation:

1. Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, People's Republic of China

2. Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, People's Republic of China

3. Hunan Province Cooperation Innovation Center for Molecular Target New Drug Study, Hengyang 421001, People's Republic of China

4. Department of Endocrinology, The People's Hospital of Peking University, Beijing 100044, People's Republic of China

5. The Maternal & Child Health Hospital of Hunan Province, Changsha 410008, People's Republic of China

6. Institute of Nutrition Science of Shanghai School for Biological Sciences, Chinese Academy of Sciences, Shanghai 20031, People's Republic of China

7. Department of Pharmacy, The Huaihua Third People's Hospital, Huaihua 418000, People's Republic of China

Abstract

Aim: To investigate the potential genetic effect on metformin efficacy in overweight or obese Chinese Type 2 diabetes mellitus (T2DM) patients. Patients & methods: 768 SNPs in or close to 207 genes were genotyped in 84 patients treated with metformin + glibenclamide/Xiaoke Pill. Significant SNPs were then verified in 107 recent-onset overweight or obese T2DM patients treated with metformin alone. Genotyping was done by Illumina GoldenGate Assay. Results: In the discovery stage, 22 SNPs were nominally significant. IL1B rs1143623 (p = 0.011) and EEF1A1P11-RPL7P9 rs10783050 (p = 0.021) were still significantly associated with the relative change of HbA1c in the replication stage. Conclusion: IL1B rs1143623 and EEF1A1P11-RPL7P9 rs10783050 polymorphisms may contribute to metformin's glucose-lowing efficacy in overweight or obese Chinese T2DM patients.

Publisher

Future Medicine Ltd

Subject

Pharmacology,Genetics,Molecular Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/pgs.15.95

Reference34 articles.

1. Global estimates of diabetes prevalence for 2013 and projections for 2035

2. Prevalence and Control of Diabetes in Chinese Adults

3. Management of Hyperglycemia in Type 2 Diabetes, 2015: A Patient-Centered Approach: Update to a Position Statement of the American Diabetes Association and the European Association for the Study of Diabetes

4. Metformin: An Update

5. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)

Cited by 7 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Genetic association of solute carrier transporter gene variants with metformin response;Balkan Journal of Medical Genetics;2021-06-01

2. The pseudogenes of eukaryotic translation elongation factors (EEFs): Role in cancer and other human diseases;Genes & Diseases;2021-04

3. The relationship between gestational diabetes mellitus and interleukin 1beta gene polymorphisms in southwest of China;Medicine;2020-10-23

4. The Correlation betweenIL-1β-C31TGene Polymorphism and Susceptibility to Breast Cancer;Journal of Breast Cancer;2019

5. Cytokine Gene Polymorphisms Associated With Various Domains of Quality of Life in Women With Breast Cancer;Journal of Pain and Symptom Management;2018-02