The Nephroprotective Effect of Zizphus Jujuba Extract Against 5-Flurouracil- Induced Nephropathy

Author:

Shoiab Ayman1,Gardouh Ahmed2

Affiliation:

1. Faculty of Pharmacy, Department of Pharmacy Practice, Jadara University, 21110 Irbid, Jordan.

2. 2Department of Pharmaceutical sciences, Faculty of Pharmacy, Jadara University, 21110 Irbid, Jordan. 3Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Suez Canal University, 41522 Ismailia, Egypt.

Abstract

This study assessed the protective effect of Zizphus jujube (ZJ) extract on 5‑FU‑induced alterations in renal function markers and kidney morphology in Dawley rats. Twenty-four rats were divided randomly into four groups administrated orally with 0.9% normal saline as the control group, 5-FU (40 mg/kg daily for 5 days), ZJ (500 mg/ kg daily for 5 days), and 5-FU‏+ ZJ (for 6 days). further biochemical experiments carried out on blood collected from the heart. Kidney tissues were obtained for analysis of catalase (Cat), glutathione S-transfers (GST), and lipid peroxide levels as well as histology analysis. 5-FU significantly reduced the enzyme activity of Cat and GST and increased levels of lipid peroxidation and plasma creatinine levels (P < 0.005). Histopathological examination showed severe wide ischemia of proximal convoluted tubule (PCT), missing in Bowman's space, and edema in the group treated with 5-FU. In addition, pretreatment with ZJ has significantly improved levels of Cat and GST and reduced lipid peroxidation and plasma creatinine levels (P < 0.05). Moreover, the histopathological analysis showed that ZJ relatively prevented the damage in renal tubular cells compared with 5-FU treated group. Supplementation with ZJ may have clinical benefit in nephrotoxicity caused by 5‑FU.

Publisher

International Scholars and Researchers Association

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