This study covers an extended spectrum of clinical cases (1) to analyze the accurate tumour size, (2) to demarcate accurate tumour boundaries in order to plan an effective target volumes for radiotherapy, thermal ablation including radiofrequency ablation and nanoparticles induced thermal ablation. Once the clinical size of the tumour is established, realistic three-dimensional volume of the tumour can be calculated. Accurate margins (0.5 cm -1 cm) can only be sacrificed if true tumour boundaries with irregular nodal spread can be retrieved.