Affiliation:
1. Kursk State Medical University
Abstract
Purpose of the study. To conduct a clinical trial of the local treatment efficacy of skin and soft tissue inflammatory processes combination with sodium carboxymethylcellulose, immobilized miramistin and metronidazole.Patients and methods. The study involved patients with purulent-inflammatory skin processes, divided into two groups – control and experimental – 30 in each. The most common nosological form were abscesses of various localization. In the control group, local treatment was carried out with dioxomethyltetrahydropyrimidine ointment with chloramphenicol, and in the experimental group – with a combination of sodium carboxymethylcellulose with miramistin and metronidazole. We studied the local temperature, wound pH, wound planimetry, the appearance of wounds, the species composition of infectious agents in the discharge from the wound, a general blood test (with the determination of leukocyte indices), blood biochemical parameters, and the number of bed-days in the hospital. The data obtained were processed statistically.Results. The percentage of reduction in the area and volume of wounds in the experimental group was significantly higher than in the control. The maximum rate of wound healing in the experimental group was noted on days 1-3 and amounted to 9.7 (6.3; 15.5) % / day, and in the control group – 5.6 (2.9; 7.7). Starting from the 5th day of treatment, the local temperature indices in the experimental group were significantly lower than in the control group, and the pH values of the wounds in the experimental group tended to neutral values from the 5th day of treatment, and in the control group there was an increase in pH. Most often, S. epidermidis and S. aureus were inoculated from the wound discharge (in total, more than 50 % of observations); in the control group, pathogenic microorganisms were inoculated 1.6 times more often than in the experimental group.Conclusion. Patients in the experimental group were hospitalized for 2.5 days less than patients in the control group. It is possible to recommend further study and application of the combination of miramistin and metronidazole immobilized on the sodium salt of carboxymethylcellulose in the treatment of wounds.
Subject
Microbiology (medical),Immunology,Immunology and Allergy
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