Identification of cross-reactive IgE-binding proteins from Philippine allergenic grass pollen extracts

Author:

Castor Mary Anne R.1ORCID,Cruz Maria Katrina Diana M.2,Balanag Gregg Austine M.2,Hate Krystal M.2,Reyes Roche Dana C.1,Agcaoili-De Jesus Maria Socorro3,Ocampo-Cervantes Cherie C.3,Dalmacio Leslie Michelle M.2

Affiliation:

1. Division of Allergy and Immunology, Department of Pediatrics, College of Medicine – Philippine General Hospital, University of the Philippines Manila

2. Department of Biochemistry and Molecular Biology, College of Medicine, University of the Philippines Manila

3. Division of Allergy and Immunology, Department of Medicine, College of Medicine – Philippine General Hospital, University of the Philippines Manila

Abstract

Background: Respiratory allergies are one of the most common allergic diseases that affect Filipinos. Grass pollen accounts for the majority of the outdoor allergens triggering these respiratory allergies. Cross-reactivity among the Philippine grass pollen grains has not been extensively studied. Objective: This study aims to investigate the cross-reactivity of our local grasses and identify the cross-reactive allergens. Methods: Grass pollen grains were collected and processed into crude allergenic extracts. The IgE-reactivity of these crude allergenic pollen extracts was studied using sera from patients who tested positive for the mentioned extracts. The proteins from the immunoblots of cross-reactive pollen allergen extracts were sequenced and identified. Results. Allergenic pollen proteins were identified as cross-reactive among the grass pollen extracts. Four of these have not been listed yet as grass allergens in the World Health Organization/International Union of Immunological Societies allergen nomenclature database. Conclusion: Local grass pollen allergens are cross-reactive with probable new allergens identified.

Publisher

Ovid Technologies (Wolters Kluwer Health)

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