Author:
Jong FX Himawan Haryanto,Gunawan Ari,Santoso Mochamad Wirono Aman,Anjani Susilowati,Tirthaningsih Ni Wayan,Basori Ahmad
Abstract
The aim of this study was to analyze the effects of ethanol extract of sambiloto (Andrographis paniculata) on fatty liver percentage, serum glutamic oxaloacetic transaminase (SGOT) level and lipid profile of wistar strain white rat exposed to high fat diet. The study used randomized post test only control group design. Total sample was 50 male wistar strain rats (Rattus norvegicus) divided randomly into 5 groups (randomization). The normality test used was Kolmogorov Smirnov test (a=0.05). The homogeneity test used was Levene test (a=0.05). The comparative test was done using Anova test (analysis of variance) (a=0.05) or Brown-Forsythe test (a=0.05). The correlation test was done using Pearson test (a=0.05). The administration of sambiloto ethanol extract with doses of 100, 200 and 400 milligrams (mg)/kilogram (kg) body weight (BW) decreased the percentage of fatty liver (r=-0.950), SGOT (r=-0.964)/SGPT (r=(R=-0.973)/LDL (low-density lipoprotein) (r=-0.960) and increased HDL (high-density lipoprotein) levels (r=-0.923)=0.956) in white rats exposed to a high-fat diet. In conclusion, increased dose of ethanol extract of sambiloto can decrease the percentage of fatty liver, SGOT/SGPT and total cholesterol/TG/LDL and increase HDL level of white rats exposed to high fat diet.
Reference18 articles.
1. . Andrographis paniculata leaf extract prevents thioacetamide-induced liver cirrhosis in rats;Bardi;Plos One 9 e,2014
2. Berlanga A, Guiu-Jurado E, Porras JA, Auguet T (2014). Molecular pathways in non-alcoholic fatty liver disease. Clin Exp Gastroenterol 7, 221-239
3. Campana B, Semela D, Heim M, Bernsmeier C (2015). Non-alcoholic fatty liver disease - changing the prevalence of liver cancer? Eur Med J Hepatol 3, 12-18
4. The molecular pathogenic role of inflammatory stress in dysregu-lation of lipid homeostasis and hepatic steatosis;Chen;Genes & Diseases,2014
5. Andrographolide prevents high-fat diet-induced obesity in C57BL/6 mice by supressing the sterol regulatory element-binding protein pathway;Ding;J Pharmacol Exp Ther,2014
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献