Membrane Stabilizing Effect of Curcumin on Chronic Cadmium Intoxication

Abstract

A new mechanism of Curcumin membrane stabilizing effect on white rats tissue cells’ membranes (brain, liver, kidneys, lungs, spleen, small intestine and heart) with chronic cadmium intoxication was defined. The white rats were divided into 3 groups (4 rats in each): 1) rats received water by drinking – control (C); 2) rats received CdSO4 with drinking water (0,3 mg/kg/day) during 28 days – (Cd ); 3) rats received CdSO4 and Curcumin (200 mg/kg/day) at the same time during 28 days (Cd+Cur). Compared to the control (C) group the specific content of total fractions of new membrane components (total fractions of superoxide-producing and thermostable associate isoforms between NADPH containing lipoprotein (NLP) and NADPH oxidase (Nox)) – NLP-Nox significantly increased in the second group, which caused a corresponding destabilization of biomembranes. In the Cd+Cur group, under the influence of Curcumin, depending on the organ, there is a tendency to approach the specific contents of total fractions of NLP-Nox isoforms of above mentioned tissues to control in varying degrees. The membranostabilizing effect of Curcumine was revealed.